This work is obviously
important and needs to be more broadly applied. There are a number
of protocols that strongly assist the body in cancer resistance
generally. That conventional medicine fails to exploit them as a
first line of defense is scandalous and difficult to credit. This is
another well documented treatment that should be applied as a matter
of course with great care to adverse reactions that may need to be
managed.
I note that this protocol
is contra indicated in the case of kidney failure, however, been
fussy in the face of cancer is also contra indicated since one is in
a foot race to stall the disease and prevent metastasis. I have
noticed this imbalance of logic before around cancer therapy. After
all it is 100% certain that a cancer will metastase. Any possibility
that slows the effect while strengthening the immune system is surely
beneficial. The reality is that the moment the individual is
diagnosed with cancer today his status becomes that of a prospective
lab rat. His best chance is to take charge of the process and become
a smart active patient because you can survive.
Otherwise the claims here
are pretty potent as are claims related to establishing an alkaline
PH for the blood. Certainly the patient needs to be applying these
protocols while the medical profession is figuring out the next step.
We now know that significant remission is possible and even
stabilization.
L-Arginine & Cancer
On December 15, 1991
the LA
Times published a
large expose about Jimmy Keller, a man dedicated to healing and
experimental medicine. The government believed he was a con man,
kidnapped him in Mexico, convicted him of fraud and put him in jail.
Interestingly and importantly, the 1999 Nobel Prize research showed
him to have been a medical genius. Almost all our understanding of
arginine, a simple amino acid, comes in the years following Keller’s
conviction.
Researchers around the
world are serious about the use of amino acids in cancer treatment.
L-arginine is the common substrate for two enzymes, arginase and
nitric oxide synthase (NOS). As a precursor to nitric oxide, it is a
key component of endothelial-derived relaxing factor. The
endothelium is the lining inside blood vessels and arginine
supplements help make more nitric oxide, which helps to relax and
dilate blood vessels. The body needs higher levels of arginine when
it is under conditions of stress, illness, malnutrition or injury.
When these conditions are present, arginine becomes essential for
healing to occur.
Dr.
Joe Prendergast, a longtime expert on the power of L-arginine says,
“Arginine uses the two
natural pathways into the brain to promote anti-aging properties,
sports performance, and boost
the immune system.
Because L-arginine promotes healthy blood flow, it can also benefit
human sexuality.” Arginine overcomes cardiovascular issues and
reverses atherosclerosis[1].
Dr. Prendergast is proud to say that all his patients through the
last 17 years have managed to not succumb to any strokes, heart
attacks or even to diabetes.
Arginine is used to treat
conditions that improve with increased blood flow, such as chest
pains, erectile dysfunction, clogged arteries, vascular disease and
headaches, according to the Mayo Clinic.
Arginine is one of the 20 most common natural amino acids and this is what Keller was injecting intelligently into his cancer patients’ veins. When he administered the amino acid solution intravenously into himself first, he was astonished. “I felt a tingling in my tumor areas. They got softer. It was phenomenal.”
Arginine is one of the 20 most common natural amino acids and this is what Keller was injecting intelligently into his cancer patients’ veins. When he administered the amino acid solution intravenously into himself first, he was astonished. “I felt a tingling in my tumor areas. They got softer. It was phenomenal.”
The LA
Times article explains
how, when Keller gave a patient an injection of Tumorex[2],
the patient would start
feeling heat in their tumor (a thermometer placed on the tumor,
Keller said, showed a temperature rise of one to two degrees). There
was a pulling, tingling, grabbing sensation.[This
is extremely important because it is known that cancer cells are
highly sensitive to heat and the cause of known spontaneous
remissions - Arclein] One patient
said it felt like a thousand little fingers pulling at her tumors.
People with brain tumors heard popping and cracking sounds as if
fireworks were going off in their heads. Tumorex
didn’t always work with everyone, but when it did, Keller said,
the results could be spectacular. Within hours, patients reported,
tumors began to soften and shrink, and within days they began to
disappear. “On open tumors,” Keller said, “you could actually
see bubbles.”
The LA
Times explains further how
visitors to the Keller clinic would be astounded. They’d tell
stories about having seen people who would come to the clinic near
death, and who, after a few days or few weeks of treatment, would be
back on their feet again, walking, shopping and ready to resume
their normal lives. Dr. George Eisberg, an Albuquerque family
physician who testified at Keller’s trial, told of escorting a
dying friend to Keller’s clinic. “I wheeled him in in a
wheelchair. He couldn’t swallow.” But as soon as Keller put him
on the IV drip, the patient’s chest pain subsided so much that for
dinner that night he went out and ordered a lobster and a pina
colada.
The Times said
that, “Keller openly practiced medicine without a license, giving
injections and megavitamin IV drips, hanging the bottles on clothes
hooks, treating as many as 20 people a day from all over the
country. He didn’t merely give injections; he would hold people’s
hands and pray with them. He put all his patients on a strict diet
of foods such as whole grains, fresh vegetables, fish, fertile eggs
and chicken breasts. He urged patients to avoid aluminum pots, red
meat, canned goods, alcohol, coffee, white flour and salt.”
According to the Times,
the easiest part of Keller’s
defense was disproving the government’s contention that the
L-arginine serum used by Keller was “ineffective as a cancer
treatment.” To refute that
assertion, one of Keller’s five attorneys put several health
researchers on the stand. They testified that computer searches of
the standard medical databases showed some 20 to 25 articles,
several of which were done at the National Cancer Institute itself,
demonstrating that L-arginine either prevented cancerous tumors in
the first place or, in the case of existing tumors, made them
significantly shrink or disappear entirely. The papers ranged
from a 1943 study showing that in 83% of the animals tested, rat
tumors disappeared within two to three weeks when injected with
L-arginine, to a 1991 Lancet study
showing that when human volunteers were injected with large doses of
L-arginine over a three-day period, their “natural-killer-cell
activity rose a mean of 91%.”
Dr. Prendergast
discusses what we can do with what we know right now about
L-arginine:
In 2011 in the
journal, Clinical Cancer
Research, scientists at the
University of Colorado Cancer Center showed that treatment with the
over-the-counter amino acid
arginine reactivates
cancer-fighting T-cells in
patients with glioblastoma, thus potentially allowing the immune
system to help cleanse the body of cancer.
Most believe that every
one of us has some cancer cells in our body all the time but our
immune system is usually successful in destroying them. It just
makes sense to have a strong immune system when fighting cancer,
whether the FDA or CDC or the American Medical Association say so or
not. We notice cancer when the cells overwhelm our immune system and
grow into a noticeable tumor, so anything that strengthens the
immune system is going to help us.
Nitric oxide (NO) can also
have a multitude of effects on other aspects of tumor biology,
including angiogenesis and metastasis. The American
Society for Nutritional Sciences said
in 1994 that arginine is a dibasic, cationic, semi-essential amino
acid with numerous roles in cellular metabolism. It serves as an
intermediate in the urea cycle and as a precursor for protein,
polyamine, creatine and nitric oxide biosynthesis. Arginine
stimulates the release of growth hormone, insulin-like growth factor
1, insulin, and prolactin. Furthermore, arginine influences
pro-inflammatory cytokine levels. The
discovery that L-arginine is the sole precursor for the
multifunctional messenger molecule, nitric oxide, led to
investigation into the role of arginine in numerous physiologic and
pathophysiologic phenomena including cancer.
In the past decade, the use of NO in the treatment of cancer has
become a new field that has rapidly gained credibility and
understanding at the biochemical and molecular levels.
Nitric oxide is an
important signaling molecule that plays a significant role in the
regulation of cancer biological functions. Accumulating evidences
have reported two facets of NO as a possible mediator of cancer
development and anti-cancer therapeutics. The paradoxical action of
NO in cancer biology depends
on concentration and
other factors. In a 2006 issue of the Journal
of Experimental Medicine, a
Johns Hopkins team said that boosting levels of nitric oxide appear
to dampen the effects of a specialized cell that diverts the immune
system away from tumors, allowing swarms of cancer-attacking T-cells
to migrate to tumor sites in the rodents.
Dr. Ivan Borrello,
professor at the Johns Hopkins Kimmel Cancer Center concluded that
arginine that raises NO levels won’t cure cancer “but could be
used in addition to standard chemotherapy or immunotherapy
treatments.” He is probably correct, but as he is saying, it could
be and should be used in addition to other safe and effective
medicinals; you will find it in my Natural Allopathic Universal and
Cancer protocols.
Oxygen,
Arginine & Cancer
Dr. Joe Prendergast
explains that one of the
basic reasons arginine would be helpful for cancer patients is its
ability to safely deliver more oxygen to oxygen-deprived tissues in
the body. The entire world of alternative medicine agrees that
getting more oxygen to the tissues is going to be bad news for any
and all cancer cells because they have given up normal respiration
for fermentation. When acid levels are high and oxygen levels are
low we find cancer flourishing—a situation that orthodox oncology
ignores.[ This explains also
the importance of achieving an alkaline blood Ph – with the maple
sugar – baking soda combo for example - Arclein]
Arginine opens up the
veins and arteries to increase blood flow and volume, thus
increasing oxygen to the cells. In my cancer protocol, we also have
magnesium increasing oxygen-carrying capacity as it relaxes blood
vessels and brings down blood pressure, and we have sodium
bicarbonate that, as every athlete knows, also makes it easier to
circulate oxygen, thus immediately increasing endurance.
Results of a study
at Howard
Hughes Medical Institute/Duke University Medical Center in
2005 showed thatadding
nitric oxide to the blood’s hemoglobin can make it deliver more
oxygen to tissues—without
boosting heart rate or constricting blood vessels. Hemoglobin is the
blood’s oxygen-carrying component. The study was led by Dr. Mark
Dewhirst, professor of radiation oncology who said, “Hemoglobin
needs its natural partner in the blood, nitric oxide, to do its job
of delivering oxygen to tissues, but current treatments deliver
hemoglobin without nitric oxide. If we could raise the level of
tumor oxygenation before radiation, we would have a better chance of
killing more of the cancer cells.”
As it turns out, breathing
in pure oxygen naturally raises the level of circulating oxygen, but
not oxygen levels in the arteries feeding tumors. But
hemoglobin plus nitric oxide, by contrast, raises oxygen levels in
the tumors. The
team’s finding in the
study above is the strongest evidence to date supporting a theory,
first developed in 1996, that nitric oxide is an innate part of the
body’s oxygen delivery system. In previous studies scientists
demonstrated that nitric oxide in blood cells is an active
regulatory molecule that senses the oxygen level in tissue
and causes
hemoglobin to undergo subtle shape changes to release its oxygen in
tissues when levels are low.
The Nobel Prize in
Physiology and Medicine was awarded in 1998 to Drs. Furchgott,
Ignarro, and Murad for their discoveries concerning “Nitric oxide
(NO) as a signaling molecule in the cardiovascular system.”
NO-inducing cell-signaling events within the cell producing it and
the diffusibility of NO to other cells have led to the discovery of
many other physiological functions in many different types of cells,
including cancer cells.
Arginine’s
many benefits:
- Aids in liver detoxification
- Detoxifies ammonia
- Increases sperm count in males
- Aids in kidney disorders and trauma
- Maximizes protein synthesis
- Helps lower cholesterol
- Stimulates blood flow
- Stimulates cerebral circulation
- Promotes optimum growth
- Helps to reduce body fat and increase lean muscle mass
- Assists the body in collagen production
- Assists in the release of growth hormones
- Assists sexual satisfaction and potency
Actions
related to its use in cancer treatment are:
- Increases oxygen-carrying capacity and delivery to cells
- Inhibits cellular replication of tumors
- Enhances immune system function
- Causes retardation of tumor growth
- Assists in the release of growth hormones
- Enhances immune response
- Improves rate of wound healing (in cases of surgical intervention)
Throwing
in the Kitchen Sink
If I have not convinced
you of the reasons why arginine should be used universally for
patients with cancer and other chronic diseases, and why I have
placed it in a key position in my Natural Allopathic Protocol, read
the following from UC
Davis Cancer Center.
Arginine deiminase, a
novel drug for cancer, is like a saw to a carpenter who has had only
a hammer, says Rick Bold, UC Davis chief of surgical oncology. It is
a tool that opens a new realm of possibilities for treating cancer
and that is beginning to generate excitement nationwide. Arginine
deiminase triggers a function inside cells known as autophagy, a
Greek term meaning “self eating” or “self digestion.”
Autophagy may be a way to kill cancer cells very specifically, or in
oncology parlances, very elegantly—that is, to kill them without
poisoning or harming normal cells as current approaches do.
The Davis group has
injected both pancreatic cancer and prostate cancer cells into
animals and treated them with arginine deiminase (a pharmaceutical
preparation), and it appeared to kill those cancer cells. They
believe it will deliver a one-two punch when used with chemo agents.
Its potential in a natural protocol would be even greater and the
use of a non-pharmaceutical-sourced arginine product would be safer
and probably more effective.
In India, scientists
at Bhabha
Atomic Research Centre have
gone into further detail saying that arginine is an effective
anti-cancer molecule if
used in proper dose in an alkaline medium,
and can prove to be a natural alternative to painful chemotherapy.
“Arginine when injected
in proper doses and in an alkaline environment (pH around 9.5) leads
to speedy disruption of tumor cells and results in disappearance of
the tumor,” said the lead researchers, who were working on the
anti-cancer molecule project since 2007. They found that
arginine disrupted
the cell membrane of cancer cells when
the alkalinity was high enough, and this will go a long way in the
non-invasive treatment of cancer.
I
hope you are catching the hint here to use
arginine with sodium bicarbonate.
In terms of dosages for arginine I would recommend the same levels
that are recommended for heart patients, which is five grams per
day. Depending on each individual, and at the discretion of
supervising health professionals, high dosages can be taken but
should be brought up slowly unless the situation is already critical
and in stage four or five.[3]
Arginine
& Prostate Cancer
There are doctors and
researchers who usually get most things wrong and who attempt to
reduce the amount of arginine in your body when treating prostate
cancer. It is typical that they would desire to manipulate the
nutritional levels driving them lower as they routinely do with most
of their pharmaceutical medications. Arginine deprivation therapy
may reduce tumors, according to some, but it is certainly playing
around with the possibility of reducing overall health of normal
cells as well. The kingdom of heaven is said to be upside down to
the way things are normally here and I would certainly choose to
increase not decrease nutrition—meaning in this case—to
supplement with high dosages of arginine rather than use
pharmaceuticals to drive arginine levels down further than they
already are in the aging and in the malnourished, which most cancer
patients are.
Contraindications
/ Side Effects
L-arginine supplements
should not be taken by pregnant and lactating women unless under the
care of a health professional and even then a broadband superfood
like spirulina would be safer and better. It should be avoided by
those with viral infections such as herpes, those with liver
diseases that cause an excess of ammonia in the system (some liver
disorders are benefited from arginine),
or those who have kidney failure.
Diabetics should be careful with arginine due to its
insulin-blocking effects but that could be counteracted when
embedded in a full protocol of other concentrated nutrients.
Schizophrenics should not take more that 30 milligrams per day.
Children who have not completed bone growth should avoid arginine
supplementation but should eat arginine-rich foods.
In general, like all
nutritional medicine, arginine has been shown to be remarkably free
of side effects for the vast majority of people who have taken
it, even
in large therapeutic doses and with greater frequency of doses.
Some have experienced diarrhea and/or nausea when taking high
therapeutic doses and one study found that several weeks of large
doses might result in thickening and coarsening of the skin in some
people.
Conclusion
Some medical scientists
believe arginine can be harmful rather than helpful in treating
cancer. Arginine supplementation is part of a strategy of giving
cancer cells the amino acids they “don’t want” while depriving
them of amino acids they need to proliferate. The important
consideration, however, is that different kinds of cancer cells have
different metabolic requirements.
Specialists in the
surgical treatment of cancer have been studying the use of
supplemental arginine in cancer treatment since the early 1990s. In
1992, these scientists reported that the only time they observed
recovery of the immune system from surgery for cancer in the upper
digestive tract was when patients received a combination of
arginine, RNA, and omega-3 fatty acids.
The amino acid arginine
has long been used as an immune-nutrient to improve the immune
function in compromised individuals, such as those suffering from
burns, sepsis (poisoning by the presence of pathogens in the blood
or tissues), or trauma; it is often
given to cancer and HIV patients as well.
Arginine is considered a “conditionally essential” amino acid,
which means that under certain circumstances, such as those just
mentioned, your body cannot synthesize adequate amounts of it and
you need to obtain it from dietary sources. Intake
of 12.5 grams of arginine per day improved immune function in
hospitalized patients; the benefits include improved T-cell counts,
lower infection rates, and shortened hospital stays.
The combination
of omega-3 fatty acids, arginine, and RNA (the Rejuvenate
formula is
exceptionally high in RNA) are also associated with a reduced risk
of post-operative complications and reduced length of hospital stay.
One of the earliest studies using arginine/omega-3 fatty acids/RNA
to improve immune function was performed at the University of
Minnesota in 1991 and involved 20 patients (aged 21-80) from the
hospital’s intensive care unit. For 7-10 days, eleven of the
patients received supplementation with a solution of 12.5
g of arginine,
11.1 g of menhaden oil rich in omega-3 fatty acids, and 1.25 g of
RNA per liter of nutrient formula, while nine patients received a
placebo. The solution was delivered
via a feeding tube inserted into the patients’ duodenums.
In another study of
cancers in the lower digestive tract, specifically colorectal
cancer, researchers found that giving cancer patients 30
grams (that’s 30,000 mg) of arginine for three days caused cancer
cells to grow more receptor sites where white blood cells could
identify and destroy them.
[4] Nitric
oxide opens the microscopic blood vessels surrounding the cancer
cells, and some might fear that this would allow the cancerous tumor
greater nourishment and an avenue to spread into other parts of the
body. But for these people the idea of using arginine as a Trojan
horse—allowing cancer killer substances like sodium bicarbonate to
overwhelm the cancer cells with blasts of alkalinity and oxygen that
are flowing in with the new blood flow—would be reassuring.
It is not a good idea for
people with pancreatic or any kind of cancer to take supplemental
arginine outside the context of a well-thought-out protocol.
Research by Dr.
Louis Ignarro has shown
that you need to consume 4,000-6,000 mg of L-arginine in each
serving to boost production of nitric oxide and receive meaningful
benefits. It is critical to read and compare labels when choosing
any cardio-health supplement. Unfortunately, many companies have
reduced the amount of ingredients they use up to 90% in order to
save money. L-arginine Plus contains 5000 mg of L-arginine and 1000
mg of L-citrulline.[5],[6] (critical
in the production of nitric oxide,[7] which
extends the body’s production of nitric oxide to over 20 hours!).
The amino acid citrulline is metabolized to yield more L-arginine,
which in turn provides the additional nitric oxide.
[1] Hardening
of the arteries (arthrosclerosis) is a disorder in which arteries
(blood vessels that carry oxygenated blood from the heart to other
parts of the body) become narrowed because fat (cholesterol deposits
called atherosclerosis) is first deposited on the inside walls of
the arteries, then becomes hardened by fibrous tissue and
calcification (arteriosclerosis). As this plaque grows, it narrows
the lumen of the artery (the space in the artery tubes), thereby
reducing both the oxygen and blood supply to the affected organ
(like the heart, eyes, kidney, legs, gut, or the brain). The plaque
may eventually severely block the artery, causing death of the
tissue supplied by the artery, for example, heart attack or
stroke;http://www.emedicinehealth.com/hardening_of_the_arteries/article_em.htm
[2] Tumorex
is an amino acid product claimed to be a powerful immune system
builder that can successfully treat cancer. It was administered
intravenously with or without dimethylsulfoxide (DMSO). Laboratory
analyses of “Tumorex” samples identified it as chemically
identical to the amino acid L-arginine.
[3] Studies
of arginine have used anywhere from 6 g to 30 g daily. The
University of Pittsburgh Medical Center reports a standard daily
dose usually consists of 2 g to 8 g, though in some conditions,
including cancer, much higher dosages may be needed.
[5] According
to Dr. Louis Ignarro you need 4-6 grams of L-arginine and 200 to
1000 mg of L-citrulline to have a therapeutic effect. Anything less
and you’re not going to get improved nitric oxide production. Dr.
Ignarro won the 1998 Nobel Prize in Medicine, along
with two other American researchers, for
discovering how your endothelium converts the essential amino acid
L-arginine into nitric oxide –
the most powerful signaling molecule of your entire cardiovascular
system. The following quotes are taken from his 2005 bestseller NO
More Heart Disease:
“My
research shows that L-arginine in doses smaller than 4 to 6 grams
produces almost zero increase in NO, so it is in essence an ‘all
or nothing’ proposition – you must receive the full dose of
L-arginine.”
“It
is the synergy between the L-arginine (in a large enough dose), the
L-citrulline, and the key antioxidants that creates dramatic
increases in your body’s nitric oxide production. Without the
proper combination of these nutrients, which so many other programs
lack, you will receive little to no benefit from NO therapy.” Info
provided by Dan Hammer, who has
a background in biology, chemistry, and exercise physiology. He used
to run one of the largest health club operations in the Chicagoland
area and has been helping people with their wellness issues for more
than 25 years.
[6] Citrulline
is found most abundantly in nature in watermelons, but is also
derived from the metabolism of arginine in your body. Little
peer-reviewed scientific information regarding effective dosages of
citrulline are available. However, a 2008 study published by
the British Journal of
Nutrition found that
short-term supplementation of citrulline in 2 to 15 g doses is safe
and well-tolerated. Another study published in 2002 by the British
Journal of Sports Medicine found
that 6 g per day of citrulline supplementation promoted aerobic
energy production and changes in muscle metabolism in healthy
subjects during exercise.