UPDATE Aubrey de Grey (of SENS) opinion - It's not a very important paper. The presence of short telomeres makes cells unhappy, and they respond by changing their behaviour in various ways, including depression of mitochondrial activity. That tells us nothing at all about what happens in the absence of short telomeres, which is what we need to know for normal aging.
NBF analogy based on Aubrey comment - having no oil in your car causes parts to wear out faster but just maintaining oil levels is not sufficient to keep your car running for hundreds of years.
Scientists previously had blamed this emergency shutdown and cell death for age-related deterioration of organs whose cells divide rapidly and are rejuvenated by reserves of adult stem cells. Such tissues include skin, intestinal lining, and blood cells, among others, which generate trillions of new cells each day of life.
However, left unanswered is how cells with less cell division, such as the heart or the liver, sustain equivalent levels of aging. The scientists felt if they could solve this mystery, they might gain new insights into how DNA damage could lead to age-related decline across all organs.
The new findings demonstrate that the telomere dysfunction and activation of p53 also trigger a wave of cellular and tissue degeneration that links telomeres to well-known mechanisms of aging that are not simply related to rapid growth and division. In other words, telomere dysfunction is not just one culprit in the declining health of advanced age. It’s the kingpin, according to DePinho and his colleagues.
DePinho published a study in Nature in January 2011 that demonstrated it was possible to reverse the symptoms of extreme aging in mice by increasing their levels of telomerase, the enzyme that maintains the health of the telomeres.
In this new, larger role, the telomere dysfunction also sets off an array of reactions leading to diminished health and longevity. For example, muscles suffer a loss of mitochondria, a cell’s chemical power plant, causing waning vitality and failure of the heart and other organs. Risks of metabolic disorders such as diabetes are increased.
In addition, the process weakens the body’s antioxidant defenses against the damaging molecules known as reactive oxygen species, or “free radicals,” that accumulate with age and exposure to stress. Until now, some researchers had labeled the decline in mitochondria or the buildup of free radicals as the primary causes of age-related ills.
Telomere dysfunction causes this wave of metabolic and organ failure, the scientists found, because when the p53 gene is activated, it represses the functions of two master regulators of metabolism, PGC1-alpha and PGC1-beta. This dialing down of the regulators diminishes metabolic processes needed to provide energy and resist stress. In the mouse experiments, the scientists showed that “knocking out” p53 in mice released the brakes on PGC1-alpha and PGC1-beta.
“This is the first study that directly links telomere dysfunction to regulators of the mitochondria and antioxidant defense via p53,” DePinho said. “The discovery of this new pathway of aging integrates a lot of different ideas people have had and gives us a better understanding of the aging process.”
By unifying several major pathways of aging under the umbrella of telomere dysfunction, he said, the findings may yield new targets for therapies. The discoveries also may underlie the relatively sudden and rapid failure of the body leading to the end of life.
“Because telomere dysfunction weakens defenses against damage by free radicals, or reactive oxygen species,” DePinho said, “we think this exposes telomeres to an accelerated rate of damage which cannot be repaired and thereby results in even more organ deterioration. In effect, it sets in motion a death spiral.”