This one more plausible strategy
that looks to at least suppress cancer growth, but unable to actually eliminate
the disease entirely. Thus anti
Metastasis strategys would also have to be implemented.
We have heard nothing more on the
nanogold protocol out of MIT yet, but that promises to be the real anti cancer
bullet. It works by preferentially slipping
into cancer cells were they can be heated by a simple application of radio
waves. It actually works and it is real
nano surgery.
In this case, we are looking for
drug pathways that do the job and this will likely produce something of use.
Scientists discover a way to kill off tumors in cancer treatment
breakthrough
Scientists from the School of Pharmacy at Queen's University Belfast
and Almac Discovery Ltd have developed a new treatment for cancer which rather
than attacking tumours directly, prevents the growth of new blood vessels in
tumours, starving them of oxygen and nutrients, thereby preventing their
growth.
Targeting tumour blood vessels is not a new concept, however, this drug
attacks the blood vessels using an entirely different pathway and therefore
could be useful for treating tumours which don't respond to or which are
resistant to current therapies of this type.
Professor Tracy Robson and her research team at Queen's, in
collaboration with researchers at Almac Discovery, developed a new drug to
disrupt the tumour blood supply. They have demonstrated that this leads to
highly effective inhibition of tumour growth in a number of models as reported
this month in Clinical Cancer Research, a journal of the American
Association for Cancer Research. Almac Discovery is developing the drug
candidate and expects to start clinical trials within the next year.
Professor Tracy Robson from the School of Pharmacy
at Queen's explains: "By understanding the anti-angiogenic potential of
the natural protein, FKBPL, we have been able to develop small peptide-based
drugs that could be delivered to prevent tumour growth by cutting off their
blood supply. This is highly effective in models of prostate and breast cancer.
"However, this also has the potential for the treatment of any
solid tumour and we're excited about continuing to work with Almac Discovery as
this drug enters clinical trials."
Dr Stephen Barr, President and Managing Director of Almac Discovery
said: "This is a first class example of a collaboration between a
university and industry to produce a novel approach to cancer therapy that has
a real chance of helping patients".
The Almac Discovery / Queen's University drug is currently undergoing
preclinical development and may provide a first-in-class therapy for targeting
tumour angiogenesis by an entirely different pathway to those agents currently approved.
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For media enquiries please contact Claire O'Callaghan on 00 44 (0)
2890975391 / 07814422572 or c.ocallaghan@qub.ac.uk
Contact: Claire O'Callaghan
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