Friday, February 7, 2020

Visual Scanning of the Chemical Structure of Single Molecules at Angstrom Resolution

We are finally getting there.  Now i do wonder what we have also missed.  The next twenty years will produce a library of empirical molecule mappings that can be checked against theory in the ultimate confirmation.

It is also a reminder how some easily defined problems can take decades address.

Real progress is terribly slow with exceptions.

My own theoretical work produces a cosmology in which we can access the scale of the neutrino and the electron.  Yet empirically we have to use photons produced by neutron based physics and that means the scales simply are way out of sync.

Technically, we argued for the Ether back in the Nineteenth century but had no way to react with it.  Guess what, we still do not and recent work has actually confirmed the predicted behavior..

Visual Scanning of the Chemical Structure of Single Molecules at Angstrom Resolution 

Brian Wang | January 29, 2020 

This visual system has 0.1 nanometer (an angstrom) resolution.

They merge the images at several different vibration modes to generate the image with the chemical structure.

Scanning Raman picoscopy (SRP) is the first optical microscopy technique that has the ability to visualize the vibrational modes of a molecule and to directly construct the structure of a molecule in real space. The protocol established in this proof-of-principle demonstration can be generalized to identify other molecular systems, and can become a more powerful tool with the aid of imaging recognition and machine learning techniques. The ability of such Ångström-resolved scanning Raman picoscopy techniques to determine the chemical structure of unknown molecules will undoubtedly arouse extensive interest of researchers in the fields of chemistry, physics, materials, biology and so on, and is expected to stimulate active research in the fields, as SRP develops into a mature and universal technology.

Above- Ångström-resolved Raman images of distinct vibrational modes for a single molecule by scanning Raman picoscopy. (a) Schematic of SRP technique. The nanocavity defined by the silver tip and substrate generates a strong and highly confined plasmonic field, which is used for the excitation and emission enhancement of the Raman signals from a single molecule. The STM topograph of a single target molecule adsorbed on Ag(100) is shown at the bottom (−0.02 V, 2 pA, 2.5 nm × 2.5 nm). 

(b) Typical Raman spectra acquired at representative positions labelled in (a): lobe (red), gap (green) and center (blue). The spectrum on the bare Ag surface is also shown in black, confirming the clean tip condition free of contamination. 


Completing full molecular structure by assembling bridging units and central metal atom. (a, b) SRP mapping images for the Raman peaks at 841 cm−1 (a) and 925 cm−1 (b), respectively. (c) Partially determined molecular structure including the bridging units. (d, e) SRP mapping images for the two low-wavenumber Raman peaks at 211 cm−1 (d) and 362 cm−1 (e), respectively. (f) Fully determined molecular structure of the Mg-porphine molecule. (g) Merged SRP image by overlaying four different image patterns shown on the right for the vibration modes at 211 cm−1, 841 cm−1, 1463 cm−1 and 3072 cm−1. (h) Artistic view of the Mg-porphine molecule showing how four colored “Legos” in (g) are assembled into a complete molecular structure, with pyrrole rings in red, pyrrole C−H bonds in yellow, bridging C−H bonds in green and central Mg atom in blue.



The strong spatial confinement of a nanocavity plasmonic field has made it possible to visualize the inner structure of a single molecule and even to distinguish its vibrational modes in real space. With such ever-improved spatial resolution, it is anticipated that full vibrational imaging of a molecule could be achieved to reveal molecular structural details. Here we demonstrate full Raman images of individual vibrational modes on the Ångström level for a single Mg-porphine molecule, revealing distinct characteristics of each vibrational mode in real space. Furthermore, by exploiting the underlying interference effect and Raman fingerprint database, we propose a new methodology for structural determination, coined as scanning Raman microscopy, to show how such ultrahigh-resolution spectromicroscopic vibrational images can be used to visually assemble the chemical structure of a single molecule through a simple Lego-like building process.

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