Treat your liver with respect. In fact i suggest that we add one other guideline to follow. It takes two to three days for your liver to heal damage caused by alcohol. This plausibly applies to most other toxins we voluntarily ingest against our better judgement.
Thus if you must, then schedule any heavy use to insure three heals of healing afterward.. Once a week is a great schedule even if you must become seriously over dosed. I provide this guidance for those who cannot avoid the problem but want to retain good health.
I hopes that helps someone out there shape their life and health.