We discuss and comment on the role agriculture will play in the containment of the CO2 problem and address protocols for terraforming the planet Earth.
A model farm template is imagined as the central methodology. A broad range of timely science news and other topics of interest are commented on.
Monday, July 21, 2014
Alzheimer’s Caused By Loss of Cannabinoids, Study Shows
is perhaps the wrong word. Interference is better. What we do have
is indications that we can understand the cannabis role in memory
loss and also in memory improvement. These substances work.
is important is that real research is underway and the results are
promising. Better late than never.
is becoming strongly indicated is that we need extensive work
applying raw marijuana juice to determine its effects on memory, the
mind and the body. The payoff is obvious but our knowledge is early
Caused By Loss of Cannabinoids, Study Shows
Clumps of protein in
the brain, called beta-amyloid plaques, are the primary marker of
Alzheimer’s disease. For long, scientists knew that these clumps
interfered with memory signals in the brain — but they weren’t
Now a team
from Stanford University School of Medicine has traced the
effects of beta-amyloid plaque to activity of the brain’s
endogenous cannabinoids, or endocannabinoids. These compounds are
produced naturally by the brain and mimic the effects of compounds in
cannabis. Among many functions, cannabinoids play a key role in
memory and learning.
Looking at brain
slices taken from rats, the researchers observed that clumps of
beta-amyloid indirectly impaired memory pathways by interfering with
the normal activity of cannabinoids.
This interference with
the brain’s cannabinoids may be the mechanism by which early memory
deficits in Alzheimer’s are formed, says Daniel Madison, PhD, who
led the study. Cannabinoids may also present a new opportunity for
treating Alzheimer’s before the disease advances, he adds.
The findings were
published June 18 in the journal Neuron.
However, Dr. Madison
says it would be inaccurate to assume that smoking cannabis could
counteract the effects of beta-amyloid plaque on memory and learning.
the brain are very transient and act only when important inputs come
in,” explains Dr. Madison. Marijuana’s main ingredient, THC, has
a much longer-lasting effect, he notes.
marijuana over minutes or hours is different: more like enhancing
everything indiscriminately, so you lose the filtering effect. It’s
like listening to five radio stations at once.”
On the other hand, a
2013 study by researchers from Neuroscience Research Australia
suggests an ingredient in marijuana called CBD could be beneficial.
The team, led by Tim Karl, PhD, found that treatment with CBD led to
drastic improvements in memory in mice genetically engineered to
mimic Alzheimer’s disease.
Besides the potential
to combat Alzheimer’s symptoms, some studies suggest cannabinoids
also hold promise in slowing progression of the disorder.