This is great news because it
suggests that a vaccine can be manufactured that through multiple applications
will confer real immunity. There are presently
convincing strategies out there able to slash populations of the mosquito but
there will always remain reservoirs of infection waiting to bite. Thus those who must accept exposure do need a
true immunization protocol.
Otherwise I am growing optimistic
that the various strategies presently been implemented particularly including
simple nets will succeed in driving this scourge out of humanities life way.
We have continued to note
continued and expanding progress over the past five years of this blog.
Malaria breakthrough by Australian researchers
Scientists in Australia
say they’ve made a breakthrough in the fight against malaria by uncovering a
key protein in people who have developed an immunity to the disease.
Researchers at Melbourne’s Burnet Institute analyzed the antibodies of
adults and children in Kenya
who had become immune over time to the parasite, carried by mosquitoes.
James Beeson, head of the institute’s Centre for Immunology and senior
author of the study, said his team examined a key malaria protein called
PfEMP1.
“The puzzle has been, what is the key point of attack of the immune
system against malaria? We’ve established that one particular protein of
malaria is the key point of attack of the immune system,” said Beeson.
Scientists discovered certain Kenyans had developed an immunity to that
protein, which means the protein could be a target for a future vaccine.
Specifically, the team studied children between ages of one and 10, as
well as adults, and the number of times they had gotten malaria. The more times
they had suffered the disease, which causes up to a million deaths year, the
more antibodies they had.
According to the study, “repeated infections over time are required to
generate antibody responses toward [the protein].”
Beeson said new research will focus on developing a vaccine to induce
that immune response to the protein.
Malaria is caused by a parasite called plasmodium, which is transmitted
through the bites of infected mosquitoes. Symptoms of malaria include fever,
headache and vomiting, and usually appear between 10 and 15 days after the
bite.
When untreated, malaria can quickly become life-threatening by
disrupting the blood supply to vital organs.
The study, published in the Journal of Clinical Investigation, also
involved research by University of Melbourne and the Kenya Medical Research
Institute.
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