It turns out that platelets are the stem cell delivery system and this is the missing part in understanding how they work. You need an active injury in order to heal at all and a robust delivery is obviously mandated.
Another obvious extension of this work will be that we run blood transfusions through a centrifuge as well and add saline to provide fluids as necessary. This allows the patient to get a jump start on general body healing after a trauma.
That it is been actively used by professional athletes legally is amusing. After all the advantage provided by steroids is just that. They accelerate recovery from a major workout and allow an almost immediate repetition on even the same day.
It is no trick to guess that we will now have platelet doping to accomplish the same trick with likely better results.
Another obvious extension of this work will be that we run blood transfusions through a centrifuge as well and add saline to provide fluids as necessary. This allows the patient to get a jump start on general body healing after a trauma.
That it is been actively used by professional athletes legally is amusing. After all the advantage provided by steroids is just that. They accelerate recovery from a major workout and allow an almost immediate repetition on even the same day.
It is no trick to guess that we will now have platelet doping to accomplish the same trick with likely better results.
I visited Dr. Purita's clinic at the Stem Cell Centers of America.
http://content.alsearsmd.com/?yuOJbjmP6PFdXNQNHefKl9rN7D87tfAQy
Dear Reader,
You
have a powerful "healing factor" flowing through your blood right now.
It's virtually unknown to mainstream medicine, and it's never been
offered to you by any doctor.
Yet
this natural substance is so potent, it has the potential to rebuild
aching joints, repair diseased organs, and make your face and skin look
15 years younger.
It's
a technology that harvests "growth factors" from the platelets in your
blood, as well as newly discovered stem cells that up until now were
completely unknown.
And I found one of the world's leaders in this field.
His name is Dr. Joseph Purita and he's one of the speakers at my upcoming Palm Beach Anti-Aging Summit in October.
The technique is called platelet-rich plasma therapy (PRP). Dr.
Purita uses it to rejuvenate old, aching joints with platelets and
their accompanying stem cells. He's had incredible results by injecting
troubled joints with PRP plus extra growth factors.
He
predicts the protocol will replace surgery for many orthopedic
troubles, like arthritis, inflamed tendons, torn muscles, injured
ligaments, and damaged joint cartilage. And studies support his
prediction. 1,2,3,4,5,6
I know PRP really works. It's a very powerful tool that helps professional athletes get back into competition faster than surgery. And sometimes it can save some athletes from having to retire after repeated, crippling injuries.
Just
a short list of world-class athletes that have used PRP include golf
pro Tiger Woods, tennis player Rafael Nadal, NBA star Kobe Bryant,
former NFL star Hines Ward, and baseball star Alex Rodriguez.
I'm
so impressed with PRP, I'm starting to use it in my own practice. I've
already started extensive new training for my staff, and I'm
investigating the best PRP equipment and advanced technology for my new
Palm Beach Institute of Anti-Aging Medicine.
Here's how it works...
Platelets are needed to clot your blood. But they do much more.
They're also your body's first responders whenever there's an injury. Platelets attract stem cells to the damaged area.
And
I've just learned about a very exciting discovery that explains why PRP
rejuvenates damaged tissue so well. I didn't know this before. Nobody knew it.
Turns out there are "very small, embryonic-like stem cells" in your circulating blood.
These
newly-discovered stem cells are different from more-specialized stem
cells because they still produce high levels of the enzyme telomerase.
Telomerase
stimulates the growth of telomeres, a cellular marker for your
biological age. The longer your telomeres, the younger you feel.
These stem cells, which are in your peripheral blood, have so much telomerase they're essentially immortal.
An injury gives these stem cells the incentive to change into working cells to repair the body. Given the right circumstances, they can become bone cells, muscle cells, brain cells or any other cells.
When
the stem cells arrive at the wound, they multiply rapidly. Then they
morph into whatever cells we need to repair the damage.
Platelets
also contain hundreds of proteins called growth factors. The natural
growth factors in PRP are critical in key stages of wound healing. They
regenerate injured tissues.7
To
make PRP, doctors draw a small amount of your blood and run it through a
centrifuge. This machine separates out red blood cells and leaves
behind plasma with a high concentration of platelets.
PRP has five to 10 times more platelets than whole blood.8 And the additional growth factors from all those platelets help heal wounds at least two to three times faster than normal.9
But you don't need to wait for this technology to make its way to your local doctor. You can get started right away with a few simple nutrients.
Activate the Healing Power of Your Stem Cells
Another of my colleagues, highly respected neurosurgeon Dr. Charles Theofilos, gives his patients a special blend of herbs, vitamins, and minerals to help awaken your body's stem cells.
Dr. Theofilos practices at The Spine Center in Palm Beach Gardens, FL. He's famous as a pioneer in developing innovative surgical devices and techniques.
The Consumers' Research Council recently named him one of "America's Top Surgeons for Neurosurgery." He was one of only 20 elite surgeons selected to participate in groundbreaking studies to compare the success of spinal-disc replacement with traditional spinal fusion.
And Dr. Theofilos has become a leader in minimally invasive treatments with PRP, stem cells and blood proteins. In keeping with this philosophy, he developed two unique natural formulations that can stimulate stem cells.
The formulations can help prevent damage to cartilage, tendons, ligaments and joints. And they can help patients rebuild their bones and connective tissue after orthopedic surgeries.
If you want to start stimulating your stem cells at home, I've come up with some recommendations based on Dr. Theofilos' formulations:
- Take 45 to 90 mcg of vitamin K2 a day. Vitamin K comes in several different forms called menaquinones. They're numbered from four to nine. The higher the number, the more bioavailable and long-lasting it will be. MK-4 and MK-7 are the most important, and that's what you'll find in a good K2 supplement. And it's fat-soluble, so take it with a meal to improve absorption.
- Take 400 IUs of vitamin E a day. Make sure you're getting a mix of the two healthiest types of this vitamin, alpha-tocopherols and tocotrienols. Avoid tocopherols labeled as "d-" or "dl-." And make sure the supplement contains no more than 200 IUs of alpha-tocopherols, or it will lessen the effects of the tocotrienols.
- Take 200 mcg of selenium. Selenium stimulates telomerase, the enzyme that helps rebuild our telomeres, which are a cellular marker for aging.10 Healthy telomeres have been linked with healthier stem cells.11
- Take 200 mg. to 350 mg. of green tea extract twice a day. The active ingredient in green tea, EGCG, can prevent and repair cell damage, including stem cells. And like selenium, green tea can stimulate the genes that activate stem cells.
Stay tuned. I'll be telling you much more about this remarkable new regenerative therapy in the months ahead.
To your good health,
Al Sears, MD, CNS
Al Sears, MD, CNS
1. Mishra, A., and Pavelko, T. "Treatment of chronic elbow tendinosis with buffered platelet-rich plasma." Am J Sports Med. 2006 Nov; 34(11): 1774-8. Epub 2006 May 30.
2. Sanchez, M., et al. "Platelet-rich therapies in the treatment of orthopaedic sport injuries." Sports Medicine. May 2009, Vol. 39, Issue 5, P345-354.
3. Sampson, S., et al. "Platelet-rich plasma injection grafts for musculoskeletal injuries: A review." Curr Rev Musculoskelet Med. 2008. 1: 165-174.z
4. Kon, E. et al. "Platelet-rich plasma: Intra-articular knee injections produced favorable results on degenerative cartilage lesions." Knee Surg Sports Traumatol Arthrosc." 2010. 18: 472-479.
5. Sampson, S., et al. "Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: A pilot study." American Journal of Physical Medicine & Rehabilitation." December 2010. Vol. 89, Issue 12, P961-969.
6. Smyth, N.A., et al. "Platelet-rich plasma in the pathologic processes of cartilage: Review of basic science evidence." Arthroscopy. 2013 August; 29(8): 1399-1409.
7. Bennett NT, Schultz GS. "Growth factors and wound healing: biochemical properties of growth factors and their receptors." Am J Surg. 1993;165:728–737.
8. Dae Hun Kim et al, "Can platelet-rich plasma be used for skin rejuvenation? Evaluation of effects of platelet-rich plasma on human dermal fibroblast." Ann Dermatol. 2011 Nov; 23(4): 424–431.
9. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. "Autologous platelets as a source of proteins for healing and tissue regeneration." Thromb Haemost. 2004;91:4–15.
10. iu Q, Wang H, Hu D, Ding C, Xiao H, Xu H, Shu B, Xu S. "Effects of sodium selenite on telomerase activity and telomere length." Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003;35(12):1117-22.
11. Hiyama, E. and Hiyama, K. "Telomere and telomerase in stem cells." Br J Cancer. 2007 April 10; 96(7): 1020-1024.
2. Sanchez, M., et al. "Platelet-rich therapies in the treatment of orthopaedic sport injuries." Sports Medicine. May 2009, Vol. 39, Issue 5, P345-354.
3. Sampson, S., et al. "Platelet-rich plasma injection grafts for musculoskeletal injuries: A review." Curr Rev Musculoskelet Med. 2008. 1: 165-174.z
4. Kon, E. et al. "Platelet-rich plasma: Intra-articular knee injections produced favorable results on degenerative cartilage lesions." Knee Surg Sports Traumatol Arthrosc." 2010. 18: 472-479.
5. Sampson, S., et al. "Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: A pilot study." American Journal of Physical Medicine & Rehabilitation." December 2010. Vol. 89, Issue 12, P961-969.
6. Smyth, N.A., et al. "Platelet-rich plasma in the pathologic processes of cartilage: Review of basic science evidence." Arthroscopy. 2013 August; 29(8): 1399-1409.
7. Bennett NT, Schultz GS. "Growth factors and wound healing: biochemical properties of growth factors and their receptors." Am J Surg. 1993;165:728–737.
8. Dae Hun Kim et al, "Can platelet-rich plasma be used for skin rejuvenation? Evaluation of effects of platelet-rich plasma on human dermal fibroblast." Ann Dermatol. 2011 Nov; 23(4): 424–431.
9. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. "Autologous platelets as a source of proteins for healing and tissue regeneration." Thromb Haemost. 2004;91:4–15.
10. iu Q, Wang H, Hu D, Ding C, Xiao H, Xu H, Shu B, Xu S. "Effects of sodium selenite on telomerase activity and telomere length." Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003;35(12):1117-22.
11. Hiyama, E. and Hiyama, K. "Telomere and telomerase in stem cells." Br J Cancer. 2007 April 10; 96(7): 1020-1024.
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