Scientists just discovered a way to turn brain cancer's worst enemy into its own destruction.

We are starting to see serious applications of nano particle tech that approaches its obvious promise.

A med coated particle slides through the blood brain batrier to do its work.

All this should be used quickly because it ususlly delivers known meds able to petrform without perhaps concentrating elsewhere.

Scientists just discovered a way to turn brain cancer's worst enemy into its own destruction.

Vincentius Liong/Leong 梁国豪

Retired Leader | 30+ Yrs in Electronic Security & Building Automation with Fortune 500 Multinational Corporation

Scientists just discovered a way to turn brain cancer's worst enemy into its own destruction. Using tiny gold nanoparticles coated with DNA, researchers have created a treatment that sneaks past the blood-brain barrier and teaches the immune system to attack glioblastoma, one of the deadliest cancers known to medicine. The results in mice were so dramatic that some lived long enough to be considered cured. This breakthrough could change everything we know about treating brain tumors. ------------ 

Glioblastoma is the kind of cancer that terrifies oncologists. It's aggressive, it hides from the immune system, and it kills most patients within 15 months of diagnosis. Traditional treatments barely make a dent because the tumor creates an immunosuppressive shield around itself, essentially telling the body's defenses to stand down. But researchers at Northwestern University and Washington University just cracked the code using something called Spherical Nucleic Acids, or SNAs. Picture tiny gold spheres, each one decorated with specialized DNA strands that activate a protein called cGAS. When these nanoparticles reach the brain tumor, they flip a molecular switch that wakes up the immune system and turns it against the cancer. https://lnkd.in/g7UNd_sa The results were stunning. Mice treated with these SNAs lived significantly longer than those receiving standard care. When combined with immune checkpoint inhibitors, the treatment was even more powerful. Some mice that were cured were later re-challenged with new tumors, and their immune systems remembered and destroyed the cancer immediately, suggesting long-term immunity. What makes this particularly exciting is the delivery method. The researchers administered the treatment intranasally, meaning through the nose. The nanoparticles traveled along the trigeminal nerve directly into the brain, bypassing the blood-brain barrier that blocks most drugs. This non-invasive approach could transform how we deliver treatments to the brain. The technology also proved effective when injected directly into tumors, working across multiple glioblastoma models. PET scans showed measurable tumor shrinkage, and analysis of the tumor environment revealed that the treatment was converting immunosuppressive cells into cancer-fighting cells. 📌Sources and References: Proceedings of the National Academy of Sciences (PNAS), November 2025, DOI: 10.1073/pnas.2409557122 Northwestern University Feinberg School of Medicine, Brain Tumor Research Washington University School of Medicine, Siteman Cancer Center ✓Read and learn more: https://lnkd.in/g7UNd_sa https://lnkd.in/gPECc5K5 https://lnkd.in/g5Dg4SYu ✓Peer-Reviewed Scientific Publications: https://lnkd.in/gniXKX_n https://lnkd.in/gxH2z8SM https://lnkd.in/gFQ2KH-j https://lnkd.in/g3fn7Bft https://lnkd.in/gczQwYyq https://lnkd.in/gr3Eq76J Credit: CTTO #EvolvedChimp