The drug, a type of histone deacetylase (HDAC) inhibitor being evaluated in numerous ongoing clinical trials, has been shown to reverse the harmful effects of autophagy in heart muscle cells of mice. Autophagy is a natural process by which cells eat their own proteins to provide needed resources in times of stress. The new study appears in Proceedings of the
Prior research from Dr. Hill’s laboratory has shown that HDAC inhibitors blunt disease-associated heart growth, so researchers designed this study to determine what impact a particular type of HDAC inhibitor had on autophagy.
The researchers engineered mice with overactive autophagy and induced hypertrophy leading to heart failure. Scientists then gave the mice an HDAC inhibitor known to limit autophagy.
“The heart decreased back to near its normal size, and heart function that had previously been declining went back to normal,” Dr. Hill said. “That is a powerful observation where disease regression, not just disease prevention, was seen.”
Dr. Hill noted that the research that led to this finding started decades ago and included studies led by Dr. Kern Wildenthal, former president of UT Southwestern and now president of Southwestern Medical Foundation.
The study was funded by the National Institutes of Health, American Heart Association, American Diabetes Association and the AHA-Jon Holden DeHaan Foundation.
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