Mammoth Intact Genetic Material Makes Cloning Possible

The necessary intact genetic material has been sourced from Siberia and that means we are on track to produce the first few Mammoth Clones inside the next five years. I am sure that most folks still refuse to credit this as possible and my guess is that the press will sleep a while on this story.

Without belaboring the point, while still requiring a fair bit of luck, the full menagerie of the Pleistocene are plausible candidates for cloning and population regeneration simply because intact frozen bones can be and have been found.   Obviously we also have an army of specialist hot on the hunt for bragging rights.

Folks may want to knock all this,  but it also teaches us how to regenerate populations of more recently extinct populations all over the world which we would love to see again, as difficult as that will be.

As I have already posted, reversal and restoration of the massive extinctions throughout the globe over the past three centuries is not impossible and indeed welcome.  Few were ever human prey but were affected by our symbiotes instead.

Woolly mammoth to be brought back to life from cloned bone marrow 'within five years'

Thigh bone discovered in permafrost soil of Siberia Contains elusive undamaged genes essential for nucleus transplantation. Nuclei of elephant's egg cells will be replaced with mammoth's marrow DNA. Embryo will then be planted into elephant womb for gestation

By SIMON TOMLINSON

Last updated at 7:45 PM on 3rd December 2011

http://www.dailymail.co.uk/sciencetech/article-2069541/Woolly-mammoth-brought-life-cloned-bone-marrow-years.html

Scientists believe it may be possible to clone a woolly mammoth within five years after finding well-preserved bone marrow in a thigh bone recovered from permafrost soil in Siberia.

Teams from Russia's Sakha Republic's mammoth museum and Japan's Kinki University will launch fully-fledged joint research next year aiming to recreate the giant mammal, Japan's Kyodo News reported from Yakutsk, Russia.

By replacing the nuclei of egg cells from an elephant with those taken from the mammoth's marrow cells, embryos with mammoth DNA can be produced, Kyodo said, citing the researchers.

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Clone hope: The discovery of marrow inside the thigh bone of a woolly mammoth in Siberia has led scientists to believe they can bring the species back to life

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Exciting: Mammoth bones like this one have been dug up many times before, but finding one with undamaged genes has proven a challenge (file picture)

The scientists will then plant the embryos into elephant wombs for delivery as the two species are close relatives, the report said.

Securing nuclei with an undamaged gene is essential for the nucleus transplantation technique, it said.

For scientists involved in the research since the late 1990s, finding nuclei with undamaged mammoth genes has been a challenge. 

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Fertile land: The thigh bone was discovered in the permafrost soil of Siberia as were these tusks which came from an entire 23,000-year-old mammoth dug up in 1999

Mammoths became extinct about 10,000 years ago.

But the discovery in August in Siberia has increased the chances of a successful cloning.

Global warming has thawed ground in eastern Russia that is usually almost permanently frozen, leading to the discoveries of a number of frozen mammoths, the report said.

Read more: http://www.dailymail.co.uk/sciencetech/article-2069541/Woolly-mammoth-brought-life-cloned-bone-marrow-years.html#ixzz1fjovfCoG