The Race to Redesign Sugar

This is the state of the art.  We do need a healthy way to supplant sugar.  altetrnately we need to find a way to sharply reduce it in our diets.

The latter option is proving to be the easiest as the Japanese used stevia to reduce sugar use by a full five percent.

We do need to drive suger out of processed food by regulation to some degree,  Our taste buds will adjust as anyone who eats oriental pasteries will notice.

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The Race to Redesign Sugar

September 28, 2020 Issue

https://www.newyorker.com/magazine/2020/09/28/the-race-to-redesign-sugar

Forget artificial sweeteners. Researchers are now developing new forms of real sugar, to deliver sweetness with fewer calories. But tricking our biology is no easy feat.

By Nicola TwilleySeptember 21, 2020

New food-industry research focusses on reformatting sucrose or using rare sugars.Illustration by Na Kim

Every workday, at ten o’clock, at noon, and at three in the afternoon, Eran Baniel receives an alert on his phone: the call to taste. When I joined him on a Monday morning in January, in an office park a few miles east of Tel Aviv, he was sitting at a desk with two white china plates of Petit Beurre cookies in front of him. The cookies looked identical, but a label identified the plate on Baniel’s left as 792, and the one on his right as 431. “Petit Beurre is our preferred platform,” Baniel told me, breaking off a corner of a 792 cookie and crunching it thoughtfully. “It’s fast to make and fast to taste.” He sipped some water, took a leftover shard of 431, and invited me to join him as he repeated the process. The second cookie tasted better somehow—a little more buttery, maybe—but that was not what Baniel was assessing. The two sets of cookies had been made with the same recipe, except that one batch contained forty per cent less sugar. The question that Baniel had to answer was: which?

Baniel, a former actor now in his mid-seventies, has expressive eyebrows and a theatrical baritone. In 2014, he became the founding C.E.O. of DouxMatok, an Israeli startup that is now releasing its first product: sugar crystals that have been redesigned to taste sweeter, so that you can put forty per cent fewer of them in a Petit Beurre and it will still taste as sweet as the original. The company has branded its sugar Incredo, a name that gestures toward the disbelief that greets any suggestion that we might be able to have our cake while eating only half the sugar, too.

At the company’s headquarters, every available surface seemed to be laden with Incredo-sweetened treats—cookies, chocolates, gummy bears, jars of cocoa-hazelnut paste. In blind tastings conducted by a consumer-research company, more than two-thirds of a panel of ordinary consumers said they preferred the Incredo Petit Beurres to the full-sugar ones, and seventy-four per cent indicated that they’d rather buy the Incredo version of Nutella than the real thing. It won’t be long before they can: later this year, Incredo will enter commercial production with Südzucker, Europe’s biggest sugar producer, as well as with one of the leading refined-sugar distributors in North America, whose identity, I was told, had to remain undisclosed.

Such secrecy is unsurprising in an industry dominated by multinational corporations all spending large amounts on research and development in pursuit of the same goal: to continue selling countless sweet things in a world that is increasingly wary of sugar. In 2015, the World Health Organization recommended that no more than ten per cent—and, ideally, less than five—of an adult’s daily energy intake should come from sugar. In other words, an average adult, with a daily consumption of two thousand calories, ought to consume no more than six teaspoons of sugar a day—the amount found in a generous schmear of Nutella, and quite a bit less than the contents of a can of Coke. The following year, the Obama Administration announced new rules requiring companies to disclose their products’ added-sugar content on the Nutrition Facts label. Some governments have gone further. Many countries, especially in Europe and South America, have begun placing health-warning labels on, and taxing, products containing more than a teaspoon or two of sugar per three ounces—a category that includes many things that people think of as innocuous, such as breakfast cookies, oatmeal muffins, and nutrition bars.

These measures seem to be having an impact. Recent surveys report that seventy per cent of Americans are concerned about the sugar in their diets, and U.K. shoppers rate sugar content as the most important factor in making healthy food choices. As public opinion turns against sugar, food companies have outdone one another in pledges to cut the quantities of it that appear in their products. Pepsi has promised that by 2025 at least two-thirds of its drinks will contain a hundred calories or fewer from added sweeteners. A consortium of candy companies, including Mars Wrigley, Ferrero, and Russell Stover, recently declared that by 2022 half of their single-serving products will contain at most two hundred calories per pack. Nestlé has resolved to use five per cent less added sugar by the end of this year—though, as of January, it still had more than twenty thousand tons of the stuff left to eliminate.

The problem is that sugar isn’t easy to replace. Despite scientists’ best efforts in the past century, none of the artificial alternatives that have been developed are quite as irresistible, let alone as versatile in the kitchen. The looming impact of new nutrition standards, combined with regulatory pressure and public sentiment, has led to something of a panic in the industry, and a flurry of innovation. The new race—in which DouxMatok is only one of several competitors—is not to develop a substitute for sugar but to design a better sugar altogether.

DouxMatok’s method of restructuring sugar crystals was invented by Baniel’s father, Avraham, an industrial chemist. He patented the technique five years ago, when he was ninety-six; today, at the age of a hundred and one, he has finally retired. At one point during my visit, Eran sifted through a pile of his father’s memorabilia—black-and-white photographs, identification cards, university certificates—to find illustrations for a forthcoming presentation about the company. Many of the photographs were new to Eran, and, as he tried to place them, the outline of his father’s life emerged: a six-year-old Polish boy sent to boarding school in what was then the British Palestine Mandate; a student at the University of Montpellier; a promising young scientist, strikingly handsome, exempted from serving in the British Army’s Palestine Regiment so that he could make bombs in the basement of a paint factory near Haifa.

After the war, Avraham helped found the newly formed State of Israel’s national mining institute. In the following decades, he was granted more than two hundred patents, for processes that ranged from turning wood chips into biofuel to synthesizing a key ingredient in carpet fibres. “The first chemical technology sold abroad by Israel was from my father,” Eran told me—a method for producing potassium nitrate that was licensed to Japanese fertilizer manufacturers in the nineteen-fifties.

Avraham began thinking about sugar in the late nineties, while he was serving as a consultant to a British food company that was launching a new artificial sweetener in the United States. Early sales had been slow, and consumer research seemed to show that children, in particular, remained resolute in preferring real sugar. Avraham was reminded of something he’d noticed back in the nineteen-forties, when sugar was strictly rationed. His neighbor, an elementary-school teacher, had asked him whether, as a chemist, he might be able to get hold of some cornstarch so that she could make a pudding. Her theory was that its thick and sticky texture would coat the tongue, helping her students’ meagre allowance of sugar seem more satisfying.

After helping his neighbor, Avraham made some pudding himself, and found that she was right: up to a point, the more viscous he made it the sweeter it tasted. Sixty years later, he began to wonder whether the best way of reducing sugar was not by replacing it but by reformatting it. Sucrose is delivered to the taste receptors on our tongues by saliva, as sugar crystals dissolve in our mouth, but only about a fifth of the sugar in a typical bite of cookie actually connects with a receptor. The rest of it is washed down into our bellies—calories we consume but never taste. “Statistically, it goes everywhere you don’t want,” Eran told me.

“Whose hair did I just find on your jacket?”

Cartoon by Justin Sheen

Searching for a way to tickle the sweet receptors more effectively, Avraham tried blending pure sucrose with various carriers. Eventually, he hit on the idea of mixing sugar with tiny grains of silica, a common ingredient in the food industry. (Silica passes through the human digestive system without being metabolized.) Each silica grain is less than a fiftieth the diameter of human hair—invisible to the eye and undetectable on the tongue. DouxMatok’s production process embeds them throughout each sugar crystal, like blueberries in a muffin.

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Even though the resulting crystal is ninety-nine per cent sugar, the addition of silica has two outsized effects: the bond between the silica and the sugar comes apart in the mouth, exposing a vastly expanded surface area of sucrose to the liquefying powers of saliva; and the sucrose immediately surrounding each silica grain changes form. The atoms in a sucrose molecule are usually stacked in a well-ordered lattice, but when this structure becomes what scientists call “amorphous,” its atoms frozen in random chaos, it dissolves on the tongue much more quickly. Incredo’s exponentially more soluble structure rapidly saturates your taste buds, delivering an intense hit of sweetness. The best analogy is cotton candy: melting sugar into an amorphous state and spinning it into a tangle of fine strands produces a confection that seems much more cloying than chocolate or soda, despite containing a fraction of the sugar.

Once Avraham had a prototype, he enlisted Eran, who is an entrepreneur rather than a scientist. (He started out in show business, producing theatre collaborations between Israelis and Palestinians, and then moved on to urban lighting projects, including illuminating the walls of the old city of Jerusalem.) They secured patents on the technology, consulted with venture capitalists and major food companies, and, in 2014, founded DouxMatok. The name means “double sweet”—or, at least, it does if you know that matok means “sweet” in Hebrew and that doux, the French for “sweet,” sounds like the Hebrew du, which means “double.”

Until the late eighteenth century, when sugar production started to become mechanized, most people consumed very little of what nutritionists call “free” or “added” sugars—sweeteners other than, say, the lactose naturally present in milk and the fructose naturally present in fruit. In 1800, an average American would have lived and died never having encountered a single manufactured candy, let alone the array of sugar-sweetened yogurts, snacks, sauces, dressings, cereals, and drinks that now line supermarket shelves. Today, that average American ingests more than nineteen teaspoons of added sugar every day. Not only does most of that never come into contact with our taste buds; our sweet receptors are also less effective than those for other tastes. Our tongues can detect bitterness at concentrations as low as a few parts per million, but, for a glass of water to taste sweet, we have to add nearly a teaspoon of sugar.

“That makes sense for what the system was designed for,” Robert Margolskee told me. He is a biologist at the Monell Chemical Senses Center, in Philadelphia, where he studies the molecular mechanisms of sweet perception. Humans, he explained, evolved in an environment filled with substances that might make us sick or even kill us, and are therefore highly sensitized to unpleasant tastes that may signal danger. But the sweetest thing that early hominids would have been likely to come across was fruit or, occasionally, honey. So although we are now surrounded by cheap, plentiful sources of sweetness, our sugar receptors are still tuned to the level of a ripe banana. “It would be better if our sweet receptors got more sensitive so we would eat less sugar,” Margolskee said. “But that’s going to take another couple hundred thousand years at least.”

It has taken only a few decades for obesity rates to triple in America. In 1960, when national surveys began, fewer than fourteen per cent of adults were obese; today, that figure is forty per cent. Sugar is not entirely to blame for this increase—annual per-capita consumption of cheese, for example, has increased eightfold in the past century, and physical activity has undoubtedly declined. Still, as early as the nineteen-twenties, this mismatch between our saturated sugarscape and our insensitive sweet receptors led doctors and diet gurus to recommend low-calorie sugar replacements. Saccharin, a coal-tar derivative favored by Theodore Roosevelt, who was diabetic, was first marketed as early as the eighteen-eighties; during the past century, it has been joined by a half-dozen competitors, most notably aspartame, which appeared in the nineteen-eighties. (Donald Rumsfeld was in charge of launching it.)

Many of these so-called “non-nutritive sweeteners” have acquired a questionable reputation—frequently perceived as both tasting bad and being bad for you. In 1951, as diet soft drinks and desserts proliferated, the sweetener sodium cyclamate was banned by the Food and Drug Administration, because it caused bladder cancer in rats. Saccharin was later also banned for many years, after some worrying studies were published in the seventies, although the current consensus is that today’s artificial sweeteners are not carcinogenic at the levels at which they’re consumed.

The issue of taste presents a greater obstacle. Saccharin is sweeter than sugar, and aspartame is almost two hundred times as sweet, but they’re not a precise match for sugar. “Unconsciously, we all know the time profile of sucrose,” Russell Keast, a food scientist at Deakin University, in Australia, told me. “The onset of sweetness, how long the peak intensity lasts, exactly how long the aftertaste lingers.” With Splenda, say, that pattern is different, and not in a way that most people enjoy. Many non-nutritive sweeteners also have metallic or bitter notes, which have to be disguised with other ingredients.

Furthermore, none of sugar’s artificial replacements offer anything close to the same range of functionality. Sucrose reduces ice-crystal formation in ice cream; it adds crispness to baked goods, volume to dough, and a mouth-filling viscosity to drinks; it improves emulsion stability in dressings, reduces grittiness in chocolate, and even increases shelf life. Manufacturers thus use it promiscuously, even in foods—mayonnaise, bread, hot sauce—in which its sweetness is imperceptible to the tongue. By contrast, saccharin gives baked goods a grainy texture, aspartame separates when heated, losing sweetness, and sucralose muffins and cakes fail to inflate. “That promise—you know, here we’ve got this wonderful compound that tells us it’s sweet, yet delivers no calories?” Keast said. “You’d have to say it’s been a gross failure.” Sugar is simply too integral to every aspect of our cuisine for any other molecule to be an adequate substitute.

Acentury ago, Henry Tate, who introduced the sugar cube to Britain, joined forces with Abram Lyle, who had made a fortune selling golden syrup (a treacly by-product of sugar refining), to found Tate & Lyle. Long a dominant force in the industry, the company eventually got out of the commodity sugar business, and today about a fifth of its profits come from the sweetener Splenda, which it developed in 1976. But, in 2010, around the time that Avraham Baniel began playing with the idea of adulterating sucrose with silica, Tate & Lyle’s scientists also began looking into ways of retooling, rather than replacing, sugar. “It was obvious at the time,” Jim Carr, the head of the company’s sweetening-technology division, told me. “Our customers wanted a natural ingredient to make things more nutritional, take calories down—so let’s see what already exists in nature.”

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Sucrose, which is derived from cane or beets, is not the only kind of sugar. As early as the seventeen-nineties, chemists extracted others from various plants. Grapes yielded the first alternative, glucose, which is one of the two building blocks of sucrose, but only three-quarters as sweet. The other is fructose, which is half as sweet again. Through the years, scientists identified dozens of naturally occurring saccharides—all variations on the basic chemical structure of sugar, which is a molecular matrix of carbon, hydrogen, and oxygen atoms. Some of these other sugars are well known: in addition to lactose and fructose, there’s amylose (from starch) and maltose (from malt). They are also metabolized as sugars in the body, which means that they have the same dietary drawbacks as sucrose.