Study Indicates Fasting Mimicking Diets Help Humans Live 2 to 5 Years Longer

 

Now that intermittent fasting has become prevalent, it is possible to do the meta stat studies that confirm the expectations produced by lab studies.  It is definately working to allow us to age better
 and obviously longer.

When i spelled out the Arclein Diet, Intermittent fasting was not a thing.  I did describe the salient biology we were taking advantage of and the real takehome is that you can use it to dump obesity itself..  You do not have to be over rigid on it either as long as you only nibble on fast days.

all this postpones diabetic events as well.

Study Indicates Fasting Mimicking Diets Help Humans Live 2 to 5 Years Longer

February 28, 2024 by Brian Wang

https://www.nextbigfuture.com/2024/02/study-indicates-fasting-mimicking-diets-help-humans-live-2-to-5-years-longer.html

Fasting-mimicking diets are associated with a decrease of 2.5 years in HUMAN median biological age, independent of weight loss.

Nearly identical findings resulted from a second clinical study (NCT04150159).

These results provide initial support for beneficial effects of the FMD on multiple cardiometabolic risk factors and biomarkers of biological age.

Caloric restriction is among the most powerful life-extending interventions in mice. However, there is a lack of experimental data on its effect on human lifespan. Continuous caloric restriction is also very hard to maintain in humans in real life. Several substitutes have been proposed, such as time-restricted eating (intermittent fasting) and periodic long-term fasting.

USC Leonard Davis School Professor Valter Longo, a renowned geroscientist, has long been advocating for a particular type of caloric restriction, a fasting-mimicking diet (FMD).

FMD Against Fatty Liver and Immunosenescence

In this new study published in Nature Communications, Longo and his team analyzed additional data from two previous studies, focusing on body composition, liver adiposity, metabolic metrics, and biological age. Those studies, which included three FMD cycles, already showed reductions in body weight, trunk and total body fat, and blood pressure without any adverse effects.

Participants who had obesity, elevated CRP, elevated fasting glucose, or systolic hypertension showed an even greater decrease in biological age of 2.9 years after undergoing FMD.

A reduction in biological age is associated with but not equal to an increase in predicted life expectancy. When the researchers tried to estimate the latter, they found that FMD increased median predicted life expectancy from 82.2 to 83.5 years.

According to that model, if someone were to undergo three FMD cycles annually, that person would only be gaining 0.85 years of biological age for every one-year increase in your chronological age. IF this regimen of three annual cycles started at the age of 50, life expectancy at 70 would be about five years higher than without FMD: 88.3 years vs 83.2 years