» Aubrey de Grey on Chemicals That Can Reverse Aging Damage

We can do two things.  We can dispose of old cells to clear the way for new cells and way more important we can turn back the age of cells and obviously stem cells as well.  All this means your cellular body can be restored to prime.  doing it will be another matter, but creating such an elixer is now a priority.

This is particularly important because the whole globe is entering a long cycle of depopulation that is best offset by life extension .  folks do have to stop dying of old age.

Of course ,we will need an expanded population to fully terraform terra even before we fully optimize our ocean and create refugias deep underground as well.  Then there is Venus in particular and every other object in our solar system occupied using refugias and artificial gravity.

100,000,000,000 is actually just a lower minimum for humanity.   wild eh?

» Aubrey de Grey on Chemicals That Can Reverse Aging Damage

Aubrey de Grey on Chemicals That Can Reverse Aging Damage

July 17, 2023 by Brian Wang

https://www.nextbigfuture.com/2023/07/aubrey-de-grey-on-chemicals-that-can-reverse-aging-damage.html#more-184864

Aubrey de Grey has been a primary leader advocating, fundraising and advancing the science of Antiaging technology for the past three decades. He provided his comment on the work of Harvard’s David Sinclair for chemically reversing cellular aging.

The work in 2018 that small molecules could kill zombie, dysfunctional old senescent cells has led to the creation of many biotech companies working on senescent cells. The drugs used to treat senescent cell are called synolytics.

Researchers have shown that senolytics can improve the reparative properties of human heart cells by eliminating senescent “zombie cells,” known to be associated with cardiovascular disease and other age-related conditions. Zombie cells release chemicals that can be harmful to nearby cells, affecting cell survival and reparative potential. The build-up of these zombie cells in our bodies promotes aging and age-related conditions, including cardiovascular disease. In lab studies, senolytics have been shown to improve conditions such as cataracts, diabetes, osteoporosis, Alzheimer’s disease, heart failure, kidney problems, and age-related loss of muscle. Overall, they have been shown to improve poor physical function and extend health span and lifespan.

Harvard’s David Sinclair and his research team have identified six chemical cocktails, which, in less than a week and without compromising cellular identity, restore a youthful genome-wide transcript profile and reverse transcriptomic age.

Rejuvenation by age reversal can be achieved, not only by genetic, but also chemical means.

Molecules that reverse cellular aging and rejuvenate human cells without altering the genome. Sinclair and his team developed high-throughput cell-based assays that distinguish young from old and senescent cells, including transcription-based aging clocks and a real-time nucleocytoplasmic compartmentalization (NCC) assay.