All of a sudden the cause of aging is not irreversible. In fact it is completely plausible that age management will become feasible if not downright easy. That legend regarding the elixer of youth is no longer far fetched at all. It could well be possible to formulate such.
At the same time youthful cells look useful as well as a restorative agent. This is a primitive method but now it is not completely futile.
It could turn out to be easy. There are other things to improve upon as well but for most folks who are generally healthy, reversing cellular life to age thirty is very useful and practical. After that the next two decades will see tissue restoration mastered as well so that all can live at a useful biological age of thirty while physically well built through muscular auto tensioning protocols..
Researchers may have discovered fountain of youth by reversing aging in human cells
http://www.gizmag.com/reversal-of-aging-human-cell-lines/37721/
Researchers in Japan have found that human aging may be able
to be delayed or even reversed, at least at the most basic level of
human cell lines. In the process, the scientists from the University of
Tsukuba also found that regulation of two genes is related to how we
age.
The new findings challenge one of the current popular
theories of aging, that lays the blame for humans' inevitable downhill
slide with mutations that accumulate in our mitochondrial DNA over time.
Mitochondrion are sometimes likened to a cellular "furnace" that
produces energy through cellular respiration. Damage to the
mitochondrial DNA results in changes or mutations in the DNA sequence
that build up and are associated with familiar signs of aging like hair
loss, osteoporosis and, of course, reduced lifespan.
So goes the theory, at least. But the Tsukuba researchers
suggest that something else may be going on within our cells. Their
research indicates that the issue may not be that mitochondrial DNA
become damaged, but rather that genes get turned "off" or "on" over
time. Most intriguing, the team led by Professor Jun-Ichi Hayashi was
able to flip the switches on a few genes back to their youthful
position, effectively reversing the aging process.
The researchers came to this conclusion by comparing the
function level of the mitochondria in fibroblast cell lines from
children under 12 years of age to those of elderly people between 80 and
97. As expected, the older cells had reduced cellular respiration, but
the older cells did not show more DNA damage than those from children.
This discovery led the team to propose that the reduced cellular
function is tied to epigenetic regulation, changes that alter the
physical structure of DNA without affecting the DNA sequence itself,
causing genes to be turned on or off. Unlike mutations that damage that
sequence, as in the other, aforementioned theory of aging, epigenetic
changes could possibly be reversed by genetically reprogramming cells to
an embryonic stem cell-like state, effectively turning back the clock
on aging.
For a broad comparison, imagine that a power surge hits
your home's electrical system. If not properly wired, irreversible
damage or even fire may result. However, imagine another home in which
the same surge trips a switch in this home's circuit breaker box. Simply
flipping that breaker back to the "on" position should make it operate
as good as new. In essence, the Tsukuba team is proposing that our DNA
may not become fried with age as previously thought, but rather simply
requires someone to access its genetic breaker box to reverse aging.
To test the theory, the researchers found two genes
associated with mitochondrial function and essentially experimented with
turning them on or off. In doing so, they were able to create defects
or restore cellular respiration. These two genes regulate glycine, an
amino acid, production in mitochondria, and in one of the more promising
findings, a 97-year-old cell line saw its cellular respiration restored
after the addition of glycine for 10 days.
The researchers' findings were published this month in the journal Scientific Reports.
Whether or not this process could be a potential fountain
of youth for humans and not just human fibroblast cell lines still
remains to be seen, with much more testing required. However, if the
theory holds, glycine supplements could one day become a powerful tool
for life extension.
Similar research from the Salk Institute
has also recently looked at other ways to slow down or stop aging at a
cellular level, while yet another team is looking into a new class of
drugs called senolytics that could help slow aging.
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