Dimethyl Sulfoxide (DMSO) and Heart Disease

Something else to pay attention to.  It is in our food in the background so we are generally doing fine, i suspect.

Complicated to play with but here sublingual works apparently.

I have not sourced it yet.

Dimethyl Sulfoxide (DMSO) and Heart Disease

Published on November 21, 2024

https://drsircus.com/cardiovascular/dimethyl-sulfoxide-dmso-and-heart-disease/?

Dimethyl sulfoxide (DMSO) is one of the safest medically active substances in existence and has been investigated for its potential effects on arterial plaque and atherosclerosis. Discovered in 1866, Russian scientist Alexander Saytzeff isolated DMSO. It was crystalline, odorless, non-toxic, and tasted like garlic when consumed.

DMSO has been shown to possess several biological effects, including antioxidant, anti-inflammatory, and antinociceptive effects, and it has been proposed to be therapeutic in many disorders, such as gastrointestinal diseases, rheumatologic diseases, and for the treatment of several manifestations of amyloidosis.

Research indicates that DMSO protects against cholesterol-induced atherosclerosis, particularly in animal models. The effects of DMSO make it useful even in the treatment of medical disorders involving head and spinal cord injury, stroke, memory dysfunction, ischemic heart disease, and a wide range of other diseases.

Sulfur is an element of the earth and essential to life. DMSO is an intermediate product of the global Sulfur Cycle, which distributes bioavailable sulfur for all animal and plant life (Parcell, 2002). DMSO, or dimethyl sulfoxide, is a colorless liquid used as a powerful solvent. DMSO is a natural substance that is produced by trees and is obtained through the processing of wood pulp. Over the years, DMSO has been the subject of numerous studies, and many researchers have found that it has many potential health benefits.

Sulfur compounds are found in all body cells and are indispensable for life. They are needed for many chemical reactions involved in the detoxification of drugs and other harmful toxins, and they have potential clinical applications in the treatment of many conditions such as depression, fibromyalgia, arthritis, interstitial cystitis, athletic injuries, congestive heart failure, diabetes, cancer, and AIDS (Parcell, 2002).

Among the sulfur compounds, DMSO probably has the most comprehensive range and the greatest number of therapeutic applications ever shown for any other single chemical. It has around 40 pharmacological properties that may be beneficial in preventing, relieving, or reversing numerous diseases (Morton, 1993). DMSO has excellent capabilities and untold therapeutic power and is one of a lineup of essential substances that qualify as capable of helping people cure incurable diseases.

DMSO also penetrates the skin and the blood-brain barrier with ease, penetrating tissues and entering the bloodstream.

A study involving rabbits demonstrated that DMSO significantly inhibited the development of atherosclerotic lesions when administered alongside an atherogenic diet high in cholesterol. Specifically, lesions were reduced by about 50% at a lower dose of DMSO and were virtually absent at higher doses.

The protective effects of DMSO appear to be independent of its impact on blood cholesterol levels. Instead, DMSO may influence the underlying mechanisms of atherosclerosis, potentially by inhibiting the activity of vascular smooth muscle cells, which are involved in plaque formation and progression.

DMSO has been shown to inhibit tissue factor expression, which plays a critical role in thrombosis and inflammation. This suggests that DMSO could help reduce the risk of thrombus formation associated with atherosclerotic plaques, further supporting its potential cardiovascular benefits.

As a source of sulfur, DMSO aids in heavy metal detoxification. Sulfur

binds with toxic heavy metals (mercury, lead, aluminum, cadmium,

arsenic, nickel) and eliminates them via urination, defecation, and sweating.

DMSO has many remarkable properties. It acts as a near-universal solvent (e.g., it interacts with many biomolecules and can easily mix with any water concentration). It’s able to pass through biological membranes without damaging them. Because of this, DMSO will rapidly enter the body (including the brain) regardless of its route of administration (e.g., within 5 minutes after going on the skin, it can be found in the blood, and within an hour, it can be found within the bones), but simultaneously does not accumulate within the body after prolonged use (and virtually none remains a week after administration).

DMSO is an effective pain killer, blocking nerve conduction fibers that produce pain. It reduces inflammation and swelling by reducing inflammatory chemicals. It improves blood supply to an area of injury by dilating blood vessels, increasing the delivery of oxygen, and reducing blood platelet stickiness. It stimulates healing, which is a key to its usefulness in any condition.

DMSO is not only a microbicide in its own right, but it is also highly effective in carrying other microbicides into inaccessible places and penetrating biofilms in which microbes are hiding. It is especially effective against mycoplasmas. Rub it onto the skin over infected areas. You may also add Lugol’s solution, non-acidified MMS, hydrogen peroxide, magnesium chloride, and other water-soluble remedies, but not kerosene, gum turpentine, essential oils, or oil-soluble remedies. For rubbing onto the skin over infected areas, dilute DMSO to 50-70%. It is an effective pain reliever and also eliminates microbes from the skin, joints, sinuses, inner ear, bones, infected roots of teeth, jawbones, and cavitations, and may stop fungus-induced hair loss.

The minimum purity of DMSO should be 99%. A suitable combined oral and topical daily amount with chronic diseases maybe 20 to 30 ml of diluted DMSO in divided doses.

DMSO (CH3)2SO is a natural substance derived from wood pulp. It is generated during the normal decomposition of plants and, therefore, is present in low concentrations in many foods. DMSO is an antioxidant. By taking up oxygen, it is converted into Methylsulfonylmethane (MSM).

There is a very long list of health benefits from using DMSO. The main ones are:

It is an all-around microbicide effective against bacteria, fungi, mycoplasmas and viruses.

It improves the immune system and reduces allergies.

It is strongly anti-inflammatory with good antioxidant properties

It blocks pain when rubbed onto affected muscles or joints.

It improves blood circulation by inhibiting the formation of blood clots and hypercoagulation.

It dissolves newly formed blood clots.

It dilates blood vessels and improves the function of the heart.

It efficiently transports molecules across cell membranes and moves through the blood-brain barrier.

It improves connective tissue, softens collagen, and stimulates wound healing.

It is a potent diuretic and very effective with chronic bladder inflammation/cystitis.

It can dissolve blood clots and prevent damage after a stroke. It improves skin conditions such as psoriasis and scleroderma and is effective with autoimmune diseases, arthritis, ulcers, cystitis, and other inflammatory conditions. With diabetes, it can improve insulin control and blood circulation. Also, eye problems have been successfully treated with DMSO, including macular degeneration, retinitis pigmentosa, glaucoma, and cataracts, sometimes just with oral use but sometimes with added remedies such as eye drops.

With cancer, it zooms explicitly in on cancer cells and can be used to carry remedies along, which is suitable for treating brain tumors that are otherwise difficult to reach. It is also beneficial with other cancers such as breast and prostate, leukemia, and lymphomas. Relatively weak (2%) solutions of DMSO were killing leukemia cells and, with the addition of suitable remedies, induced a variety of cancer cells to become normal cells. DMSO has been shown to protect against radiation damage, especially with cancer treatment. DMSO can contribute positively to the overall efficacy of cancer treatment as a safe, inexpensive adjuvant and effective differentiation-inducing therapeutic agent.

Eliminating Circulatory Obstructions

Most of the studies discussing DMSO’s interactions with the heart regard its ability to protect it from permanent ischemia-reperfusion injuries (e.g., heart attacks). In a 2012 study, rat hearts had their blood supply cut off for 30 minutes and then were reperfused for 120 minutes. DMSO being given beforehand reduced the resulting tissue necrosis (death). A 1987 study found that DMSO increased the heart’s cardiac output during a heart attack.

A rat study found that DMSO prevented ischemia-reperfusion injuries from causing severe contractures in heart cells and the formation of contraction bands, and this seemed to be linked to DMSO reducing the oxygen-induced creatine kinase release from cells.

A key component of regenerative medicine is using stem cells (which have the potential to differentiate into many different cells) to replace damaged tissues (particularly those within critical organs). DMSO was shown to cause stem cells to differentiate into heart cells.

DMSO was found to prevent heart damage caused by dietary copper deficiency.

DMSO For Vascular Health

DMSO provides a variety of anti-clotting activities that are similar to (but eclipse) the effects of aspirin and, unlike aspirin, does not have any associated adverse effects

DMSO is remarkably effective at eliminating circulatory obstructions (e.g., clots). A leading DMSO researcher found that 50% of patients with Raynaud’s syndrome had their symptoms eliminated with DMSO and that thrombophlebitis responds excellently to DMSO.

Likewise, DMSO has been shown to improve diabetic circulatory impairments such as peripheral neuropathy or diabetic ulcers (where one study of hundreds of patients reported over a 94% treatment success rate) and prevent future amputations.

DMSO (topically and especially intravenously) is also quite helpful for varicose veins, in some cases improving the varicose veins within minutes and having the wiggly veins not reappear for months, which has been hypothesized to result from DMSO strengthening the vessel walls and their tone alongside generally improving venous and capillary circulation. Likewise, a study of 67 patients with varicose ulcers (39 females and 28 males) found they had a remarkable response to DMSO (even chronic ulcers that had been present for years).

DMSO prevents blood clot formation in the body and is a powerful platelet deaggregator (which prevents clotting). For example, it was found to reverse the reduction of coronary blood flow induced by a critical stenosis on the canine [dog] circumflex coronary artery without changing their other circulatory parameters.

DMSO is a sulf-hydryl inhibitor (which platelets need to bond) and a hydroxyl radical scavenger (which also inhibits platelet function).

DMSO inhibits tissue factor (T.F.) expression (a key part of clot formation—especially in the presence of TNF-α), thrombus (clot) formation, and vascular smooth muscle cell activation. T.F. (a platelet protein) is a key link between inflammation and blood clotting.

It increases cAMP (cAMP inhibits platelet aggregators) by inhibiting one or more of the platelet enzymes that breaks cAMP down (PDE2, PDE3, and PDE5—which is how many circulation improving drugs like Viagra also work, along with certain cognitive improving ones).

DMSO and Strokes

Dr. Gabriela Segura writes, “Given soon after a stroke, DMSO can dissolve the clot that causes the stroke, restoring circulation and avoiding paralysis. Once DMSO gets into the body, either by being daubed on the skin, given in I.V., or by mouth, it permeates the body and crosses the brain barrier, so even taking it orally can improve circulation. Ideally, it should be I.V. in critical situations.Effectively treated ischemic strokes.

Had no risk of worsening a hemorrhagic stroke.

It could easily be taken at home and, more importantly, be quickly given in ambulances.

Protected brain tissue from dying.

Prevented reperfusion injuries.

Healed damaged brain tissue after a stroke.

Radiation and Sulfur

Radiation produces free radicals (“inflammatory molecules”) that damage cells that makeup tissues such as organs, glands, muscles, and bones. Besides causing the cells to age more quickly, they also become distorted or mutated, creating cancers such as leukemia, anemia, congenital disabilities, and other diseases.

Sulfur has a long history of use as an antidote for acute exposure to radioactive material. DMSO is the classical sulfur compound. A Japanese study showed that even low concentrations of DMSO had radio-protective effects through the facilitation of DNA double-strand break repair, protecting against radiation damage at all cellular levels in the whole body.

Transdermal Application By Walter Last

When applying DMSO for transdermal treatment, the skin should be clean and free of undesirable chemicals, such as those from commercial lotions or sunscreens. DMSO can be used on its own and applied over inflamed, stiff, or painful muscles or joints or over troublesome organs, or it can be used to carry remedies or nutrients through the skin into the body.

However, it does not carry microbes, large molecules, or chemicals into the body that generally cannot penetrate the skin. It only enhances the absorption rate of those that can penetrate on their own but at a much lower rate. To avoid skin irritation, apply DMSO in diluted form at 70% or less. Some products on the market are already diluted.

For everyday use, you may make a treatment solution, e.g., in another glass bottle, by diluting full-strength DMSO. To make it about 70%, mix two parts of 100% DMSO with 1 part of water, and for a weaker solution (50%), mix equal parts of DMSO and water.

Be careful; the solution gets warm when mixing DMSO with water, and while it does not harm the skin, spills may damage painted or plastic surfaces. Strength for topical use may vary according to the sensitivity of the skin. DMSO is not generally used on broken or open skin, but it has been applied to fresh cuts and other wounds and significantly speeds up healing without causing pain or other discomfort. Depending on the degree of pain or inflammation, DMSO may be applied several times during the day over the area of pain. Still, the need for multiple applications may be reduced in the following days. The effect may be felt within minutes. Also, swellings from sprained ankles can quickly disappear if kept covered with DMSO.

While DMSO mixes freely with water and glycerine, it does not mix with oils or kerosene. It does not dissolve magnesium chloride, but it can improve absorption by carrying along water in which the magnesium is dissolved. Alpha lipoic acid dissolves very well in DMSO, Glutathione, and Coenzyme Q10 to some degree. Transdermal application of these may give a better absorption rate than oral use.

Oral Intake By Walter Last

Dr Stanley Jacob working with DMSO in the 1960s

Oral intake is the other primary form of DMSO use. As to its safety, Dr Stanley Jacob, who pioneered the medical use of DMSO, has taken an ounce (approximately 29 ml) of it orally every day for more than 40 years. The only side-effect seems to be that he has not been sick in years.

Others have taken even higher doses for weeks or months. DMSO is effective in heart attacks and angina; prompt use of it in heart attacks has been credited with preventing damage to heart muscle, but relatively high doses should be used. Dr Morton Walker suggested 2 grams per kilogram of body weight in treating heart attacks.

Except for emergencies, it is always best to start with low doses, such as half a teaspoon in a drink, and increase gradually to the intended maximum or until there is some unexplained reaction. Generally effective healing methods tend to induce some reaction, be it microbial die-off effects, skin eruptions, or gastrointestinal effects, such as diarrhea. In such a case, temporarily cut back and gradually increase again when the reaction subsides.

A suitable daily maximum intake of chronic diseases maybe 20 to 30 ml in divided doses, and it is good to take it in a drink with specific supplements to enhance their absorption. As with all supplements, It is also good not to remain at the same dose for a long time but slowly cycle up and down between a maximum and a minimum level. Finally, as long as there are problems in specific body parts, topical applications are preferred in addition to oral applications.

While DMSO is widely used in most countries as a medical drug, in the USA, it is only approved for the treatment of interstitial cystitis. In Australia, DMSO cannot be used for treating humans, but it can be sold and used for veterinary purposes and as a solvent.

Only purified and properly diluted DMSO should be used. When you dilute a pure DMSO solution, always do it in distilled water. When it is applied, the skin site and the applying hand should be thoroughly cleaned before application. This is of utmost importance as DMSO’s properties allow contaminants to be absorbed through the skin and transported into the bloodstream.

Sublingual Intake

I have been dosing DMSO like I am doing chlorine dioxide, spraying it into my mouth and holding it for a minute, then adding water to my mouth, holding a little more than swallowing. You will get to feel the strong impact of your medicine. I am taking 20 sprays of a fifty percent solution and repeat the dose after a few minutes.

Conclusion

If you search for DMSO on the U.S. National Library of Medicine (pubmed.gov), you’ll get almost 30,000 indexed results, making it one of the most studied compounds of our time. DMSO is a common chemical that can be manufactured cheaply. No drug company can get an exclusive patent since it is a natural compound. So, the medical-industrial complex ensures doctors stay as far away as possible from this basic and helpful substance.