It appears from this that aspirin
draws out the nitric oxide and in the process slows the development of
plaques. This begs the question of
nitric oxide’s role in the body and if it is a prime mover of heart disease. It is certainly suggestive.
Aspirin therapy is now
common and is recommended for anyone over fifty. Recall ninety percent of all men have CVD at
the age of sixty and this is the one safe thing one can do to minimize the
effect and real danger. Get medical
advice of course and use coated forms of the medicine to avoid rare spot damage
in the intestine.
Why is nitric oxide in the
walls and is it concentrated?
Even slowing the
progression of plaques gives the body the time to properly encase and seal of
what damage exists. This could explain
the drop in heart attack rate.
Released: 12/1/2010 4:00 PM EST
Source: Florida Atlantic University
FAU principal investigator who was the first to demonstrate that
aspirin prevents a first heart attack or first stroke publishes new mechanism
in Journal of Cardiovascular Pharmacology and Therapeutics
Newswise — Charles H.
Hennekens, M.D., DrPH, the first Sir Richard Doll Research Professor in the
Charles E. Schmidt College of Medicine at Florida Atlantic University, has
published the results of A Randomized Trial of Aspirin at Clinically Relevant
Doses and Nitric Oxide Formation in Humans in the current issue of the Journal of Cardiovascular Pharmacology and
Therapeutics. These are the first data in humans to show that all doses
of aspirin used in clinical practice increase nitric oxide. Nitric oxide is
released from the blood vessel wall and may decrease the development and
progression of plaques leading to heart attacks and strokes.
Hennekens and his
colleagues randomized patients at high risk of a first heart attack or stroke
to different doses of aspirin for 12 weeks. All doses produced highly
significant beneficial effects on two important and well documented markers of
nitric oxide formation.
Hennekens was also the
first researcher to demonstrate that aspirin prevents a first heart attack.
“While the ability of aspirin to decrease the clumping of blood platelets is
sufficient to explain why the drug decreases risks of heart attacks and
strokes, these data suggest a new and novel mechanism,” said Hennekens.
Hennekens and his
colleagues are proposing new and longer term research to the National
Institutes of Health to test whether this hypothesis has clinical or public
health relevance.
The American Heart
Association recommends aspirin use for patients who have had a myocardial
infarction (heart attack), unstable angina, ischemic stroke (caused by blood
clot) or transient ischemic attacks (TIAs or "little strokes"), if
not contraindicated. This recommendation is based on a large body of evidence
from randomized trials showing that aspirin reduces risks of heart attack,
stroke and death from vascular diseases. In primary prevention, aspirin
prevents a first heart attack, but the data on stroke and vascular death are
not yet conclusive. The decision as to whether to use the drug should be an
individual clinical judgment by the healthcare provider.
– FAU –
About Florida Atlantic
University
No comments:
Post a Comment