Aspirin Alternative

The quick take home is that we have a superior blood thinner without the specific side effects of aspirin.  I expect that it will drift into clinical use as more studies are done.  Aspirin's use as a blood thinner was never a first choice and this is clearly superior and safer as well.



In any event the more choices the better.

Aspirin was a natural solution with nasty side effects that were neutralized successfully.  It was always begging for a better solution.

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The Aspirin Alternative Your Doctor Never Told You About



Sayer Ji, 


Waking Times



Millions use aspirin daily without realizing its true dangers. The good news is that there is a natural alternative which preliminary research indicates is safer and more effective.


Aspirin is taken faithfully by millions every day as a preventive measure against heart attack, often without the user having any awareness of the serious health risks associated with it, some potentially fatal. You can view over 60 adverse effects of aspirin on the GreenMedInfo.com’s aspirin research page if you have any doubts about how serious a concern this is.


Aspirin’s widespread popularity is based on its much-touted blood-thinning properties. But there are safer, surprisingly more effective and far more natural alternatives on the market today.


For instance, pycnogenol, a branded form of an extract of French maritime pine bark, can be found on the shelves of thousands of health food stores around the country, and unique among natural products, has a broad base of human clinical research supporting its use for a wide variety of health conditions. You can view GreenMedInfo.com’s pycnogenol research page take a look at the published research.


Moreover, in cross comparison tests, pycnogenol has been found at least as effective as aspirin in preventing blood from clotting, but at significantly lower doses and with a superior safety profile.



Smoker’s Study Proves Pycnogenol More Effective and Safer Than Aspirin


In a previous article titled, “The Powerful Aspirin Alternative That Grows on Trees,” we featured a 1999 clinical study published in Thrombotic Research that found that when habitual smokers were given either 500 mg of aspirin or anywhere between 100-200 mg of pycnogenol, the pycnogenol group experienced equivalent platelet aggregation inhibiting effects but with much lower bleeding times:



“Thus, smoking-induced enhanced platelet aggregation was inhibited by 500 mg Aspirin as well as by a lower range of 100-125 mg Pycnogenol. Aspirin significantly (p<0 .001="" 167="" 236="" advantageous="" an="" bleeding="" did="" for="" from="" increased="" not.these="" observations="" p="" pycnogenol.="" pycnogenol="" ratio="" risk-benefit="" seconds="" suggest="" time="" to="" while="">

This is a highly significant finding, as aspirin-induced bleeding can result in significantly increased morbidity and mortality. One might ask, if pycnogenol is as effective a ‘blood thinner’ as aspirin but without the same side effects, then what is the downside of using the natural alternative?

New Study Confirms Pycnogenol’s Superiority to Aspirin

Research comparing pycnogenol to aspirin as a blood thinner has been sparse, but a new study promises to add additional weight to the previously reported finding of pycnogenol’s superiority. Published this year in the Italian journal Panminerva Medica and titled, “Recurrence of retinal vein thrombosis with Pycnogenol® or Aspirin® supplementation: a registry study,” researchers compared the use of either pycnogenol or aspirin in the prevention of retinal vein thrombosis recurrence after a first episode.

Retinal vein thrombosis is considered to be a relatively common condition intimately related to other conditions that afflict the vascular system, such as hypertension, arteriosclerosis and diabetes.[1]

The study methods were described as follows:

Possible management options – chosen by patients – were: standard management; standard management + oral Aspirin® 100 mg once/day (if there were no tolerability problems before admission); standard management + Pycnogenol® two 50 mg capsules per day (for a total of 100 mg/day). Number of subjects, age, sex, distribution, percentage of smokers, and vision were comparable.”

The results were reported as follows:



Recurrent RVT was seen in 17.39% of controls and in 3.56% of subjects supplemented with Pycnogenol® (P<0 .05="" 15.38="" 26="" 2="" 4.32="" 4.88="" 6="" 7.69="" 9="" a="" also="" and="" antiplatelets="" at="" be="" better="" compared="" comparison="" completed="" controls="" does="" dropped="" during="" edema="" effects.="" episodes="" equivalent="" follow-up="" for="" good="" group="" groups.="" has="" hemorrhagic="" higher="" in="" incidence="" indicates="" induce="" it="" level="" linked="" lower="" management="" may="" minor="" months="" nbsp="" new="" nine="" not="" observed="" of="" or="" other="" out="" p="" pilot="" problems.="" profile.="" recurrence="" reduce="" reduced="" registry="" retinal="" rvt="" safety="" seems="" side="" significantly="" spirin="" standard="" subclinical="" subjects="" supplement="" supplementation="" that="" the="" theoretically="" there="" this="" times="" to="" tolerability="" use="" using="" very="" vision="" vs.="" was="" were="" with="" without="" ycnogenol="">

As you can see, the clear winner in this comparison study was pycnogenol. Not only was the incidence of recurrent retinal vein thrombosis almost five times higher in the aspirin group, vision and retinal swelling (edema) was significantly lower in the pycnogenol group, as well. Moreover, whereas the pycnogenol group had no reported side effects, 6 of the 26 subjects in the aspirin group dropped out due to tolerability issues, and 7.69% of the aspirin group (2 subjects of 26) were found to have retinal bleeding as a side effect in the follow-up period.

Nature Provides Time-Tested Solutions

We really shouldn’t be surprised that a naturally occurring complex of phytocompounds (i.e. pycnogenol) should outperform a synthetic drug, considering that our bodies have co-evolved for millions of years with natural things, (e.g. foods, herbs, spices), and only a hundred or more with synthetic ones, (e.g. patent drugs). Pycnogenol, as a bark extract, is about 65-75 percent proanthocyanidins (procyanidins), a class of polyphenols found in a wide variety of plants, many of which have been in the human diet since the inception of our species and before. Some classical examples include green and black tea, cranberry, bilberry, cocoa beans, cinnamon, and black currant. Polyphenols, of course, are powerful antoxidants, as well as signaling molecules, which likely perform a variety of gene-regulatory functions, that may have value in a wide range of health conditions. Indeed, we have indexed over 150 health benefits linked to polyphenol consumption on our database alone.

Suffice it to say that as the biomedical machine moves forward, and we see an increasingly voluminous body of literature investigating the health benefits and mechanisms of action underpinning natural interventions for disease prevention and treatment, we will become increasingly compelled to choose time-tested, natural alternatives to synthetic chemicals, as the former are not only much safer but often more effective than most scientists and physicians ever dreamed possible.

WARNING: Never discontinue a pharmaceutical product without the guidance of a physician. Doing so could have serious, if not life threatening side effects. This article is for informational purposes only. Nothing here is intended as or should be substituted for medical advice. 

Additional References

[1] Prisco D, Marcucci R. Retinal vein thrombosis: risk factors, pathogenesis and therapeutic approach. Pathophysiol Haemost Thromb. 2002 Sep-Dec;32(5-6):308-11. Review. PubMed PMID: 13679663.