Gut Bacteria and Obesity

The microbiome is making steady progress into our medical system.  It is powerfully indicated as the key protocol for a wide range of diseases.  What we have learned already is that improper balance in the gut is key to understanding autism, and mind related issues generally.  Add in diabetes and its partner in heart disease and it is central to general good health.  

So it is not just obesity but obesity is something we can now clearly target with appropriate protocols that allow the fat to discharge without the body fighting back.

This science is been pieced together now and it only seriously began in the past five years or so.  Works I am presently reading tells me that it is reaching critical mass although a ways yet from total acceptance.  Right now it is the last option after repeated medical failure.

Gut bacteria 'may be obesity weapon'

By James Gallagher

Health and science reporter, BBC News

5 September 2013 Last updated at 14:14 ET

http://www.bbc.co.uk/news/health-23970219

Bacteria living in our guts seem to be affecting our waistlines and harnessing them could lead to new ways of shedding the pounds, US research suggests.

The human body is teeming with thousands of species of microbes that affect health.

A study showed that transplanting gut bacteria from obese people into mice led to the animals gaining weight, while bacteria from lean people kept them slim.

The findings were published in Science.

Researchers at the Washington University School of Medicine, Missouri, took gut bacteria from pairs of twins - one obese, one thin.

We don't dine alone, we dine with trillions of friends - we have to consider the microbes which live in our gut”

Prof Jeffrey GordonWashington University School of Medicine

The bacteria were then put into mice which had grown up in completely sterile environments and had no gut bacteria of their own.

Mice with the obese twin's bacteria became heavier and put on more fat than mice given bacteria from a lean twin - and it was not down to the amount of food being eaten.

There were differences in the number and types of bacteria species from the lean and obese twin.

Overall it seemed those from a lean twin were better at breaking down fibre into short-chain fatty acids. It meant the body was taking up more energy from the gut, but the chemicals were preventing fatty tissue from building up and increased the amount of energy being burned.

One of the researchers, Prof Jeffrey Gordon, told the BBC's Science in Action programme: "We don't dine alone, we dine with trillions of friends - we have to consider the microbes which live in our gut."

However, the diet was also important for creating the right conditions for the lean twin's bacteria to flourish. A bacterial obesity therapy seems unlikely to work alongside a a diet of greasy burgers.

Keeping both sets of mice in the same cage kept them both lean if they were fed a low-fat, high-fibre diet. Mice are coprophagic, meaning they eat each other's droppings, and the lean twin's bacteria were passed into the mice which started with bacteria that should have made them obese.

However, a high-fat, low-fibre diet meant the mice still piled on the pounds.

Human therapies?

A human obesity treatment is unlikely to use transplants of thousands of species of bacteria from lean people's guts as it carries the risk of also transferring infectious diseases.

Instead a search for the exact mix of bacteria which benefit weight - and the right foods to promote their growth - is more likely.

Prof Gordon said the next steps in the field would be "trying to figure out how general these effects are, what diet ingredients may promote their beneficial activities and to look forward to a time when food and the value of food is considered in light of the microbes that live in our gut - that foods will have to be designed from the inside out as well as from the outside in."

Commenting on the research, Prof Julian Parkhill, from the Wellcome Trust Sanger Institute, said he expected a future when manipulating bacteria was a part of obesity treatment.

"There's a lot of work to do, but this is proof of concept that bacteria in the gut can modulate obesity in adults, but it is diet-dependent," he said.

He added that changing bacteria was a promising field for other diseases.

He told the BBC: "It's an exciting new area, but I think we need to be careful in promoting it as a cure-all.

"It's clear in specific areas - inflammatory bowel disease, obesity, Crohn's - the microbiome is going to be important."