Reading Meta DNA Code

Slowly but surely, we are unraveling the mechanics of genetic coding, even it we are a long way from truly managing it all ourselves.  Yet reading this, one cannot feel but rather hopeful that we are going to be able to totally manage the whole story.

In the not too distant future we can expect a generation of robust humanity working well into the parameters available to us but still totally adapted to our world.  This will be great news and welcome.  We have all lived with weaknesses and their unsatisfactory resolution.

This will be the true inheritance of mankind, particularly if it includes a redesign of femininity that ends the late stage of child birth at least with a technological solution.  Our natural system has never been satisfactory when one recalls the extraordinary historical death rate.  If nothing else were to be fixed, then that alone would suffice.

How proteins read meta DNA code

http://archaeologynewsnetwork.blogspot.ca/2013/03/how-proteins-read-meta-dna-code.html

Scientists have accurately calculated the sliding mechanism for deciphering the second genetic code written within the DNA base pair sequence.

Three-quarters of the DNA in evolved organisms is wrapped around proteins, forming the basic unit of DNA packaging called nucleosomes, like a thread around a spool. The problem lies in understanding how DNA can then be read by such proteins. Now, Arman Fathizadeh, a physicist at Sharif University of Technology in Tehran, Iran, and colleagues have created a model showing how proteins move along DNA, in a paper just published in EPJ E.

The problem is that until now, we did not clearly understand the physical mechanisms of how to "open the book" to read the genetic text contained in DNA. Studying the dynamics of the nucleosome over reasonable time scales by means of molecular dynamics simulations is out of the question, as it would be too complex. Instead, the authors developed a basic computer model of the nucleosome in which DNA is described by a sequence of rigid blocks representing the base pairs. By introducing flexible binding sites of the DNA to the protein core, it provides a more physical representation of the system.. It also makes it possible to identify the sliding mechanism of nucleosomes along the DNA.

The idea is that a small defect in the form of a missing or extra base pair enters the DNA section wrapped around a nucleosome. This defect can then diffuse through the wrapped DNA and once it leaves the other end of the wrapped section, the nucleosome moves by the extra or missing length that the defect carried with it. This model supports the idea of a second genetic code, previously suggested in 2006. This would consist of a mechanical code written down within the base pair sequence and multiplexed with the traditional genetic code.