The good news is that restoring a natural microbial foundation will
induce recovery. Doing that is the trick.
My own problem was solved by the application of dilute hydrogen
peroxide. This obviously blew out the microbes and then natural
restoration rest the colonies.
It also explains the general failure of antibiotics as a curative.
Not only are the antibiotics internal to an external issue, the
reduction of the colonies will never be complete and their recovery
will likely mirror the original situation.
At least now we know which is which and can target the problem
directly and make the solution far better.
Sinusitis Linked to
Microbial Diversity
Released: 9/12/2012
3:00 PM EDT
UCSF Study Suggests
New Approach for Dealing with Common Ailment
Newswise — A common
bacteria ever-present on the human skin and previously considered
harmless, may, in fact, be the culprit behind chronic sinusitis, a
painful, recurring swelling of the sinuses that strikes more than one
in ten Americans each year, according to a study by scientists at the
University of California, San Francisco.
The team reports this
week in the journal Science Translational Medicine that
sinusitis may be linked to the loss of normal microbial diversity
within the sinuses following an infection and the subsequent
colonization of the sinuses by the culprit bacterium, which is called
Corynebacterium tuberculostearicum.
In their study, the
researchers compared the microbial communities in samples from the
sinuses of 10 patients with sinusitis and from 10 healthy people, and
showed that the sinusitis patients lacked a slew of bacteria that
were present in the healthy individuals. The patients also had large
increases in the amount of Corynebacterium tuberculostearicum in
their sinuses, which are located in the forehead, cheeks and eyes.
The team also
identified a common bacterium found within the sinuses of healthy
people called Lactobacillus sakei that seems to help the body
naturally ward off sinusitis. In laboratory experiments, inoculating
mice with this one bacterium defended them against the condition.
“Presumably these
are sinus-protective species,” said Susan Lynch, PhD, an associate
professor of medicine and director of the Colitis and Crohn’s
Disease Microbiome Research Core at UCSF.
What it all suggests,
she added, is that the sinuses are home to a diverse “microbiome”
that includes protective bacteria. These “microbial shields” are
lost during chronic sinusitis, she said, and restoring the natural
microbial ecology may be a way of mitigating this common condition.
A Painful, Costly
Condition
Sinuses are air-filled
cavities in the front of the skull that connect to the nasal passages
and are lined with mucosal surfaces. They are somewhat shrouded in
mystery. Scientists are not entirely sure what they do. They may
exist to heat air as it passes into the body, they may be associated
with the immune system, or as Lynch and her colleagues speculate,
they may represent a site of microbial surveillance just inside the
nose where the body can sample bacteria and other microbes entering
the body.
Though the sinuses’
underlying purpose is still unclear, they are all too familiar to
American doctors and their patients because of what happens when the
thin tissues lining them become inflamed, as occurs in chronic
sinusitis—one of the most common reasons why people go to the
doctor in the United States. There are about 30 million cases each
year, and the cost to the healthcare system is an estimated $2.4
billion dollars annually.
The pain of sinusitis
can last for months. Doctors typically prescribe bacteria-killing
antibiotics and, in more severe and long-lasting cases, conduct sinus
surgeries. However, said Andrew Goldberg, MSCE, MD, the director of
rhinology and sinus surgery at UCSF and a co-author on the paper,
“the premise for our understanding of chronic sinusitis and
therapeutic treatment appears to be wrong, and a different
therapeutic strategy seems appropriate.”
The new work suggests
that if the underlying cause of sinusitis is due to changes to the
microbiome of bacterial species colonizing sinus tissue, restoring
the naturally-occurring, protective bacteria to these cavities may be
an effective way to treat this condition.
However, the UCSF-led
team warned that the promise of this discovery does not offer an
immediate new treatment or cure for sinusitis. Any new approaches
based on these observations still have to be developed and tested for
safety and effectiveness in human clinical trials.
The article, “Sinus
Microbiome Diversity Depletion and Corynebacterium tuberculostearicum
Enrichment Mediates Rhinosinusitis” by Nicole A. Abreu,
Nabeetha A. Nagalingam, Yuanlin Song, Frederick C. Roediger, Steven
D. Pletcher, Andrew N. Goldberg, and Susan V. Lynch appears in the
September 12, 2012, issue of Science Translational Medicine.
See: http://stm.sciencemag.org/
In addition to UCSF,
authors on this study are affiliated with San Francisco State
University, the University of California Berkley, and Fudan
University in Shanghai, China.
This study was
supported by the American Rhinological Society, the Rainin
Foundation, the National Institute of Allergy and Infectious Diseases
(one of the National Institutes of Health), the Minority Biomedical
Research Support-Research Initiative for Scientific Enhancement
(MBRS-RISE), the California Institute for Regenerative Medicine, and
the Rebecca Susan Buffett Foundation.
Lynch is a member of
the advisory board of Second Genome, which is developing treatments
for human diseases based on microbiome research, and she is one of
three co-authors on the paper who have filed a patent application for
sinusitis diagnostics and treatments.
UCSF is a leading
university dedicated to promoting health worldwide through advanced
biomedical research, graduate-level education in the life sciences
and health professions, and excellence in patient care.
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