Cancer Breath Test

This is rather important for lung cancer risks.  Particularly since it can also differentiate between types, it actually becomes a clear first choice.  Scan and the follow up biopsy is hard on the patient, while this promise to be just as good and it is likely that a simple repetition a few weeks later will bring the accuracy up to the present level.

I do not know whether other cancers just happen to also leave a trace in the lungs also but it is certainly a conjecture that I would not rule out.  Our body expels gases and fluids through every external surface, so it seems likely that the lungs would pick up the signature of other cancers as a matter of course.  Certainly, it is already established that dogs pick up on the odors associated with a cancer.

A breath test may just turn out to be the best diagnostic protocol available.

Cancer Breath Test with 83% accuracy Enters Clinical Trials and next generation system is 100 times more sensitive

FEBRUARY 15, 2012

http://nextbigfuture.com/2012/02/cancer-breath-test-with-83-accuracy.html

Metabolomx, has developed technology enabling the identification of lung cancer from breath. Using the first generation of our breath analysis system,the Cleveland Clinic announced the results of a 237 subject trial at the American College of Chest Physicians conference in November 2010, reporting 81%, accuracy of lung cancer detection, comparable to CT scan, the present gold standard. This study, further reported that lung cancer subtype (small cell, adenocarcinoma, and squamous cell) is identified by the breath exam. The Cleveland Clinic has now commenced testing of the current generation Metabolomx sensor, over 100 times more sensitive than the version used in the study

Human breath contains hundreds of volatile organic compounds (VOCs) produced both endogenously and from external environmental sources. To detect the few metabolite biomarkers of disease in the background of hundreds of other VOCs a breath analysis system must be highly dimensional, able to distinguish the signature pattern of diverse VOC biomarkers in a diverse chemical background. The metabolite biomarkers are often important at very low part per billion (ppb) concentrations. Therefore it is critical the breath analysis system sensor be very sensitive, able to detect diverse VOC biomarkers often in low single digit ppb concentration. The Metabolomx sensor has the high dimensionality and sensitivity to capture the chemical signature pattern of the complex mixture of VOC’s present in breath.

Technology Review - Metabolomx, a startup in Mountain View, California, recently completed a clinical trial that shows that its breath test can spot lung cancer with 83 percent accuracy and can also distinguish between several different types of the disease, something that usually requires a biopsy. The accuracy of the test matches what's possible with low-dose computerized tomography imaging of the lungs.

Colorimetric sensor array

At the core of the Metabolomx breath analysis system is a novel, proprietary colorimetric sensor array (CSA). The CSA is a matrix of colored chemical indicators of diverse reactivities embedded in a nanoporous sol-gel matrix. Each indicator has distinct chemical reactivity with volatile species and changes color differently upon exposure to analytes. The resulting pattern of color changes comprises a high-dimensional chemical signature pattern. The image below demonstrates the patterns produced by 10 distinct bacteria, all 10 of which were identified accurately (98.8%) in 50 blind trials. Note that even different strains of the same species cause distinct patterns.

The sensor is constructed on a simple plastic or paper like media. The sensor is inexpensive and disposable. The cost and performance easily match the requirements for a one time use medical exam. The CSA exam card used in the Metabolomx breath analysis instrument is printed on a plastic substrate, contained in a tube, through which breath can be passed. The exam card is disposable, one is used with each patient exam.