Tags: algae, alternative medicine, anti-angiogenic, anti-cancer, anti-tumor, anticancer, cancer, cancer research, fucoidan, JAK-STAT3, men's health, natural cures, natural medicine, natural remedies, natural treatment, Prostate cancer, prostate health, research, seaweed
- The researchers treated DU-145 human prostate cancer cells with 100–1000 μg/mL of fucoidan.
- Using MTT, EdU, Transwell, and Matrigel cell assays, they studied cell viability, proliferation, migration and tube formation respectively.
- They injected athymic nude mice with DU-145 cells to induce xenograft model and then treated the animals with 20 mg/kg of fucoidan for 28 days via oral gavage.
- The researchers took note of tumor volume, tumor weight, vascular density in the tumor tissue, and protein expression and phosphorylation of JAK and STAT3 pathways.
- Researchers found that that fucoidan inhibited the viability and proliferation of DU-145 cells. Cell assays revealed mitigated cell migration and tube formation.
- The 28-day animal showed inhibited angiogenesis and hindered tumor growth.
- The treatment reduced phosphorylated JAK and STAT3 in the tumor tissue and limited the activation of STAT3-regulated genes, such as VEGF, Bcl-xL, and Cyclin D1.