- 1Computational Neuroscience Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
- 2Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM, USA
Methods and Results
Table 1. Desired characteristics of drugs for continuous IV infusion (Miller, 1994).
Figure 1. Structure of a standard two-compartment (plus effect site) pharmacokinetic model with transfer and elimination rates.
Figure 2. Fitting of two-compartment model with enzymatic clearance to blood sample data. (A) 0.4 mg/kg bolus; (B) 0.2 mg/kg bolus.
Figure 4. Simulated time course of plasma and effect site DMT concentration using the (Gouzoulis-Mayfrank et al., 2005) protocol.
Figure 5. Simulated time course of infusion protocol designed to reach and maintain effect site concentration of ~100 ng/ml.
For example, in the case of working through trauma, re-experiencing the feared stimulus in the altered state might be initiated with induction into a mildly altered state of relatively brief duration. In the course of treatment, a more prolonged and intense altered level of consciousness could be applied to a more extensive working through process, broadening and deepening the therapeutic gains begun with shorter and lighter exposures.