Thursday, March 24, 2016

Vaccine Delays Nicotine Effects in Mice Brains

Following the positive animal testing, the researchers are now working to refine the vaccine in preparation ... 





An interesting strategy that could work out.  It could also apply to other addictive substances as well.

Yet it also appears to be a slow acting protocol as it will need the allow for the slow dissapation of the active molecule targeted.

In the end though all our strategies do essentially that.  It is all about helping you stay quit while the body readjusts..

Vaccine delays nicotine effects in mice brains – could it help humans kick the habit?

Chris Wood March 10, 2016

Following the positive animal testing, the researchers are now working to refine the vaccine in preparation for clinical trials (Credit: TBEC Review).

The health benefits of quitting smoking are undeniably huge, but actually doing so can be extremely difficult. A new research project is hoping to make things a little easier, with scientists developing a vaccine to help people in the effort. It's looking fairly promising, with the treatment proving effective in tests on laboratory mice.

We've been trying to come up with tools to help smokers kick the habit for years, but so far, nothing has really hit the mark. Nicotine gum and patches can be effective, but don't work well all the time, and drugs have been developed that target nicotine receptors, but they've been found to cause severe side effects, including depression and mood swings.

Recently, scientists have been trying to come up with a vaccine that actually targets the nicotine molecule itself, but two recent clinical trials have failed to produce significant positive results. They did however give researchers a hint that they were on the right track, showing that the people most likely to stop smoking for a period of six months or more, were those who produced the most anti-nicotine antibodies.

In light of the results, scientists from the Scripps Research Institute in San Diego worked to create a new vaccine design, with increased numbers of antibodies that specifically target nicotine molecules. The vaccine was tested on laboratory mice, where it began to delay the effects of nicotine within just ten minutes of injection, while lowering the concentration of nicotine in the brain.

While the results of the new vaccine are positive, animal testing doesn't always accurately predict how the substance will perform in trials with human patients. The researchers are now working to refine the vaccine design, looking towards clinical trials in the future.

The findings of the research were published in the Journal of Medicinal Chemistry.

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