The most certain way in which to deliver a desired outcome is to either make it profitable or unprofitable. A baby can figure all that out. Prohibition makes the marketing and sale of drugs easy and highly profitable. Regulated access without significant penalties along with a vigorous tax regime suppresses the whole sector and makes it ordinary business.
The public is looking for safer recreational drugs. Alcohol is marginal. Marijuana happens to be less so. Others are even better and need to be studied.
The rest hurt you and that makes them naturally unattractive to the user who has an alternative.
Having a glass of fine wine or a pint of stout is a benefit. Any more is changing the experience. That must hold true for all plausible drugs that can be worked with..