- Glyphosate induces T47D, hormone dependent breast cancer cell growth.
- The proliferative effect of glyphosate is mediated via estrogen receptors.
- Glyphosate induces ERE [Estrogen Response Element]-transcription activity via estrogen receptors.
- Glyphosate modulates the expression of E[strogen] R[eceptor] α and E[estrogen] R[eceptor]β in human breast cancer cells.
Thursday, June 20, 2013
Glyphosate (Roundup) Carcinogenic In the Parts Per Trillion Range
This is one interpretation of these results and a disturbing one. Yet the low levels may well mean that another unidentified factor is at work. Regardless, we need to see a lot of work done on this problem to properly evaluate roundup as a risk factor. This work is at present suggestive.
Roundup has also been implicated in the suppression of amphibian populations mostly because Roundup is the only obvious human vector. You can see the problem there. After all we finally got wise to bird flu.
In 1965, we saw Roundup for the first time and my father read the fine print and came to the conclusion that it was way more risky than allowed in the literature. He even opined that it could cause cancer then. We took it back. I have no idea what got his back up unless the makers saw a real need to be over due the legal warnings.
It has been a valuable herbicide for need. Chronic use was never indicated and that is likely our problem.
Glyphosate (Roundup) Carcinogenic In the Parts Per Trillion Range
June 17, 2013
An alarming new study finds that glyphosate, the active ingredient in Roundup weedkiller, is estrogenic and drives breast cancer cell proliferation in the parts-per-trillion range. Does this help explain the massive mammary tumors that the only long term animal feeding study on Roundup and GM corn ever performed recently found?
An alarming new study, accepted for publication in the journal Food and Chemical Toxicology last month, indicates that glyphosate, the world’s most widely used herbicide due to its widespread use in genetically engineered agriculture, is capable of driving estrogen receptor mediated breast cancer cell proliferation within the infinitesimal parts per trillion concentration range.[i]
The study, titled, “Glyphosate induces human breast cancer cells growth via estrogen receptors,” compared the effect of glyphosate on hormone-dependent and hormone-independent breast cancer cell lines, finding that glyphosate stimulates hormone-dependent cancer cell lines in what the study authors describe as “low and environmentally relevant concentrations.”
The results were broken down by the researchers as follows:
These effects indicate that glyphosate is a ‘xenoestrogen,’ capable of inducing Estrogen Response Elements (EREs) in a manner, slightly weaker but functionally similar to the most potent human estrogen Estradiol (E2).
More concerning is the discovery that infinitesimal glyphosate concentrations in the parts-per-trillion rage (10 to the minus 12) had proliferative (carcinogenic) effects on the studied T47D breast cancer cells line:
The researchers also discovered that the naturally occurring phytoestrogen in soybean known as genistein, produced “an additive estrogenic effect” when combined with glyphosate, raising the serious question as to whether GMO soybeans are contributing to the epidemic levels of breast cancer within countries like the US where they are consumed in relatively high quantities.
It should be noted that the concentrations used to determine the interactive effects of glyphosate and phytoestrogen genistein in this study were modeled “as in a real world situation” by using information obtained from studies that assayed the respective levels of genistein and glyphosate in GM soybeans, as well as human plasma and urine concentrations following their consumption and/or exposure. For instance, glyphosate concentrations have been detected within human urine within the 0.1 – 233 parts per billion range on the lowest end, and an estimated systemic dose of 0.004 mg/kg on the high end.
The authors stated:
This finding should raise concern about the existence of more than one xenoestrogen such as phytoestrogen and contaminants in plant derived food which may be beneficial or harmful depending on the hormonal and pathological status of consumers. This study implied that the additive effect of glyphosate and genistein in postmenopausal woman may induce cancer cell growth. In this present in vitro study, we showed an estrogenicity of pure glyphosate. In summary, we found that glyphosate exhibited a weaker estrogenic activity than estradiol. Furthermore, this study demonstrated the additive estrogenic effects of glyphosate and genistein which implied that the use of glyphosate-contaminated soybean products asdietary supplements may pose a risk of breast cancer because of their potential additive estrogenicity.” [emphasis added]
This finding is relevant to virtually anyone who consumes genetically modified food today. GM crops, which are designed to survive glyphosate poisoning by being genetically engineered with ‘glyphosate-resistance” (i.e. RoundUp Ready), are universally contaminated with glyphosate and its toxic metabolite AMPA. Furthermore, glyphosate pollution and exposure is now omnipresent, with one 2011 study finding glyphosate in 60-100% of all US air and rain samples tested, and another 2012 study finding that glyphosate widely contaminates groundwater, which is the water located beneath the ground surface, that supplies aquifers, wells and springs. It is therefore virtually impossible to hermetically seal yourself off from the growing global environmental threat by only consuming “certified organic” food. The time has come to face the fact that unless there is a systemic change in the way our GM, petrochemically-driven monocultured food production system operates, we will all experience a great deal of harm.
GM Food/Roundup Breast Cancer Link Already Firmly Established
This latest study is not the only compelling evidence that there is a Roundup-Breast Cancer link. In a previous article titled, “Will the GMO-Breast Cancer Link Be Pinkwashed Away?“, we addressed the disturbing implications of the first long-term GM and Roundup animal feeding study produced by Gilles-Éric Séralini’s research team last November, and which found that after 90 days (the temporal threshold beneath which all previous biotech industry funded GM food safety studies end) the animals began to show disturbing signs of systemic organ damage, failure and cancer. More pointedly, Séralini’s team observed that the animals developed massive, estrogen-dependent mammary tumors:
“Suffering inducing euthanasia and deaths corresponded mostly in females to the development of large mammary tumors. These appeared to be clearly related to the various treatments when compared to the control groups. These tumors are generally known to be mostly estrogen-dependent (Harvell et al., 2000). We observed a strikingly marked induction of mammary tumors by R[roundup] alone, a major formulated pesticide, even at the very lowest dose administered. R[oundup] has been shown to disrupt aromatase which synthesizes estrogens (Richard et al., 2005)… [pg. 9]“
Could the results of this latest study help explain the molecular mechanism behind this finding?
About the Author
Sayer Ji is an author, researcher, lecturer, and advisory board member of the National Health Federation.
He founded Greenmedinfo.com in 2008 in order to provide the world an open access, evidence-based resource supporting natural and integrative modalities. It is internationally recognized as the largest and most widely referenced health resource of its kind.
[i] Siriporn Thongprakaisang, Apinya Thiantanawat, Nuchanart Rangkadilok, Tawit Suriyo, Jutamaad Satayavivad. Glyphosate induces human breast cancer cells growth via estrogen receptors.Food Chem Toxicol. 2013 Jun 8. Epub 2013 Jun 8. PMID: 23756170